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L-Methionine

L-Methionine Structure
CAS No.
63-68-3
Chemical Name:
L-Methionine
Synonyms
METHIONINE;MET;H-MET-OH;L-MET;L-Met-OH;l-methionin;H-L-MET-OH;lactet;Met-bNA;Acimethin
CBNumber:
CB9208759
Molecular Formula:
C5H11NO2S
Molecular Weight:
149.21
MOL File:
63-68-3.mol
MSDS File:
SDS
Modify Date:
2024/7/24 13:33:21
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L-Methionine Properties

Melting point 284 °C (dec.)(lit.)
alpha 23.25 º (c=2, 6N HCl)
Boiling point 393.91°C (estimate)
Density 1,34g/cm
refractive index 1.5216 (estimate)
storage temp. 20-25°C
solubility 1 M HCl: 0.5 M at 20 °C, clear, colorless
form Solid
pka 2.13(at 25℃)
color White
PH 5-7 (10g/l, H2O, 20℃)
Odor Slight characteristic
optical activity [α]20/D +23.7±0.5°, c = 5% in 5 M HCl
Water Solubility Soluble
λmax λ: 260 nm Amax: 0.40
λ: 280 nm Amax: 0.05
Merck 14,5975
BRN 1722294
Stability Stable. Incompatible with strong oxidizing agents.
LogP 0.217 (est)
CAS DataBase Reference 63-68-3(CAS DataBase Reference)
NIST Chemistry Reference L-Methionine(63-68-3)
EPA Substance Registry System L-Methionine (63-68-3)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P501-P270-P264-P301+P312+P330
Risk Statements  33
Safety Statements  24/25
WGK Germany  2
RTECS  PD0457000
F  10-23
TSCA  Yes
HS Code  29304010
Toxicity LD50 oral in rat: 36gm/kg
NFPA 704
0
1 0

L-Methionine price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M9625 L-Methionine reagent grade, ≥98% (HPLC) 63-68-3 5G ₹1861.9 2022-06-14 Buy
Sigma-Aldrich(India) M9625 L-Methionine reagent grade, ≥98% (HPLC) 63-68-3 25G ₹3301.63 2022-06-14 Buy
Sigma-Aldrich(India) M9625 L-Methionine reagent grade, ≥98% (HPLC) 63-68-3 100G ₹8097.1 2022-06-14 Buy
Sigma-Aldrich(India) PHR1241 L-Methionine Pharmaceutical Secondary Standard; Certified Reference Material 63-68-3 1G ₹8107.93 2022-06-14 Buy
Sigma-Aldrich(India) M9625 L-Methionine reagent grade, ≥98% (HPLC) 63-68-3 500G ₹23674.28 2022-06-14 Buy
Product number Packaging Price Buy
M9625 5G ₹1861.9 Buy
M9625 25G ₹3301.63 Buy
M9625 100G ₹8097.1 Buy
PHR1241 1G ₹8107.93 Buy
M9625 500G ₹23674.28 Buy

L-Methionine Chemical Properties,Uses,Production

Description

Colorless or white lustrous plates, or a white crystalline powder. It has a slight, characteristic odor. It is soluble in water, in alkali solutions, and in dilute mineral acids. It is slightly soluble in alcohol and practically insoluble in ether.

Chemical Properties

White crystalline powder

Uses

L-Methionine is used as an essential amino acid for human development and therapeutically acts as an antidote for acetaminophen poisoning. It serves as a chelating agent for heavy metals, as a flavoring agent and nutritional supplement for foods. It acts as a feed additive, vegetable oil enrichment and as a single cell protein. In addition to this, it is used as a hepatoprotectant and also acts as a lipotropic agent and prevents excess fat buildup in the liver.

Production Methods

Numerous methods have been described for manufacture of methionine, including hydrolysis of methionine amide )and 5-(bmethylmercaptoethyl)- hydantoin.

Definition

ChEBI: The L-enantiomer of methionine.

Preparation

The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae.  The production is carried out in a  continuously operated fixed-bed or enzyme  membrane reactor.

General Description

Minute hexagonal plates from dilute alcohol.

Air & Water Reactions

Reacts with water, steam, and/or acids to produce toxic and flammable vapors of hydrogen sulfide . Water soluble . pH of 1% aqueous solution is 5.6-6.0.

Reactivity Profile

An organosulfide and amine derivative, carboxylic acid. Look at Reactive Groups 20 (organosulfides), 7 (amines), and 3 (carboxylic acids) may give indications about reactive tendencies. L-Methionine is an amino acid essential in human nutrition.

Health Hazard

ACUTE/CHRONIC HAZARDS: L-Methionine is dangerous when heated to decomposition; it emits dangerous and highly toxic fumes.

Fire Hazard

Flash point data for L-Methionine is not available, but L-Methionine is probably combustible.

Pharmaceutical Applications

Methionine is used in oral pharmaceutical formulations as a flavoring agent.It has been included in parenteral formulations as a pH controlling agent,and it has also been used experimentally as an antioxidant with antibodies.Methionine is also used therapeutically in oral tablets

Safety Profile

Mildly toxic by ingestion and intraperitoneal routes. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. An essential sulfur-containing amino acid. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Safety

Methionine is used in oral pharmaceutical formulations. The pure form of methionine is mildly toxic by ingestion and by the IP route.
LD50 (rat, IP): 4.328 g/k
LD50 (rat, oral): 36 g/kg

storage

Methionine is sensitive to light and should be stored in a cool, dark place.

Purification Methods

Crystallise L-methionine from aqueous EtOH. Also purify it by dissolving ~0.5g of amino acid in ~10mL of hot H2O, filtering, adjusting the pH to 5.8 with 5N HCl, collecting the solid after addition of ~20mL of EtOH. It is recrystallised by dissolving in H2O and adding EtOH. It sublimes at 197-208o/0.3mm with 99.8% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Milne & Peng J Am Chem Soc 79 647 1957, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2125-2152 1961, Beilstein 4 IV 3189.]

Incompatibilities

Methionine is incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablets). Included in parenteral preparations (injection solutions; powders for reconstitution) licensed in the UK.

L-Methionine Preparation Products And Raw materials

Raw materials

Acrolein Cupric acetate monohydrate Storage tank METHYL MERCAPTAN Acetyl DL-methionine
Ammonium bicarbonate Potassium bisulfate Potassium sulfate Sodium hydroxide Ammonium chloride
Sodium cyanide (S)-2-[{(allyloxy)carbonyl}amino]-4-(methylthio)butanoic acid 5'-deoxy-5'-fluoroadenosine BOC-L-Methionine methyl methionate
FMOC-L-Methionine L-METHIONINE SULFOXIDE
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Preparation Products

N-Acetyl-L-methionine H-TYR-GLY-GLY-PHE-MET-OH DL-Methionine L-Selenomethionine L-Leucine
D-Methionine
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L-Methionine Suppliers

Global( 1000)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
AMINO ORGANICS +919866989891 Hyderabad, India 275 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
Dodhia Group +91-9619867345 +91-9619867345 Mumbai, India 129 58 Inquiry
SYNOVA CHEMICALS +91-9920741772 +91-9920741772 Mumbai, India 428 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Meteoric Biopharmaceuticals Pvt. Ltd. +91-8511121361 +91-8511121361 Mumbai, India 71 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
Scientific OEM +91-22- 2343 7546 / 2341 3094 New Delhi, India 1996 38 Inquiry
ALPHA CHEMIKA +91-22-22061123 +91-22-66382501 Mumbai, India 1681 43 Inquiry
Supplier Advantage
AMINO ORGANICS 58
JSK Chemicals 58
Dodhia Group 58
SYNOVA CHEMICALS 58
HRV Global Life Sciences 58
Meteoric Biopharmaceuticals Pvt. Ltd. 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
CHEMSWORTH 30
Scientific OEM 38
ALPHA CHEMIKA 43

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