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DL-Methionine

DL-Methionine Structure
CAS No.
59-51-8
Chemical Name:
DL-Methionine
Synonyms
METHIONINE;MET;L-MET;H-MET-OH;RACEMETHIONINE;Urimeth;200-432-1;Thiomedon;H-L-MET-OH;DL-2-Amino
CBNumber:
CB6208758
Molecular Formula:
C5H11NO2S
Molecular Weight:
149.21
MOL File:
59-51-8.mol
MSDS File:
SDS
Modify Date:
2024/9/5 22:20:32
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DL-Methionine Properties

Melting point 284 °C (dec.)(lit.)
alpha -1～+1°(D/20℃)(c=8,HCl)
Boiling point 306.9±37.0 °C(Predicted)
Density 1.34
FEMA 3301 | D,L-METHIONINE
refractive index 1.5216 (estimate)
storage temp. 2-8°C
solubility 1 M HCl: 0.5 M at 20 °C, clear, colorless
pka 2.13(at 25℃)
form Crystals or Crystalline Powder
color White
Odor mild sulfurous acidic
Odor Type acidic
optical activity [α]/D, c = 5 in 5 M HCl (inactive)
Water Solubility 2.9 g/100 mL (20 ºC)
Merck 14,5975
JECFA Number 1424
BRN 636185
BCS Class 1
Stability Stable. Incompatible with strong oxidising agents.
InChIKey FFEARJCKVFRZRR-UHFFFAOYSA-N
LogP 0.37
CAS DataBase Reference 59-51-8(CAS DataBase Reference)
NIST Chemistry Reference Methionine(59-51-8)
EPA Substance Registry System Methionine (59-51-8)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  33-36/37/38
Safety Statements  24/25-36-26
WGK Germany  2
RTECS  PD0457000
F  10-23
TSCA  Yes
HS Code  29304090
NFPA 704
1
1 0

DL-Methionine price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) W330108 DL-Methionine 99%, FCC, FG 59-51-8 1SAMPLE ₹5141.88 2022-06-14 Buy
Sigma-Aldrich(India) W330108 DL-Methionine 99%, FCC, FG 59-51-8 1KG ₹8540.93 2022-06-14 Buy
Sigma-Aldrich(India) W330108 DL-Methionine 99%, FCC, FG 59-51-8 5KG ₹29195.03 2022-06-14 Buy
Sigma-Aldrich(India) W330108 DL-Methionine 99%, FCC, FG 59-51-8 10KG ₹46136.15 2022-06-14 Buy
Sigma-Aldrich(India) M9500 DL-Methionine ≥99% 59-51-8 100G ₹2836.15 2022-06-14 Buy
Product number Packaging Price Buy
W330108 1SAMPLE ₹5141.88 Buy
W330108 1KG ₹8540.93 Buy
W330108 5KG ₹29195.03 Buy
W330108 10KG ₹46136.15 Buy
M9500 100G ₹2836.15 Buy

DL-Methionine Chemical Properties,Uses,Production

Description

Methionine is an α-amino acid with the chemical formula HO2CCH(NH2)CH2CH2SCH3. This essential amino acid is classified as nonpolar. This amino-acid is coded by the initiation codon AUG which indicates mRNA's coding region where translation into protein begins.

Chemical Properties

White crystalline powder

Occurrence

High levels of methionine can be found in eggs, sesame seeds, Brazil nuts, fish, meats and some other plant seeds; methionine is also found in cereal grains. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine. Racemic methionine is sometimes added as an ingredient to pet foods.

Uses

DL-Methionine is sometimes given as a supplement to dogs; it helps keep dogs from damaging grass by reducing the pH of the urine.
Methionine is allowed as a supplement to organic poultry feed under the US certified organic program.

Preparation

By addition of methanethiol to acrolein; by chemical conversion of methylthiopropionic aldehyde.

Definition

ChEBI: A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.

Biosynthesis

As an essential amino acid, methionine is not synthesized de novo in humans, who must ingest methionine or methioninecontaining proteins. In plants and microorganisms, methionine is synthesized via a pathway that uses both aspartic acid and cysteine. First, aspartic acid is converted via β-aspartyl-semialdehyde into homoserine, introducing the pair of contiguous methylene groups. Homoserine converts to O-succinyl homoserine, which then reacts with cysteine to produce cystathionine, which is cleaved to yield homocysteine. Subsequent methylation of the thiol group by folates affords methionine. Both cystathionine-γ-synthase and cystathionine- β-lyase require pyridoxyl-5′-phosphate as a cofactor, whereas homocysteine methyltransferase requires vitamin B12 as a cofactor.

Biological Functions

Together with cysteine, methionine is one of two sulfurcontaining proteinogenic amino acids. Its derivative S-adenosyl methionine (SAM) serves as a methyl donor. Methionine is an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine, and other phospholipids. Improper conversion of methionine can lead to atherosclerosis.
This amino acid is also used by plants for synthesis of ethylene. The process is known as the Yang Cycle or the methionine cycle.
Methionine is one of only two amino acids encoded by a single codon (AUG) in the standard genetic code (tryptophan, encoded by UGG, is the other). The codon AUG is also the most common eukaryote "Start" message for a ribosome that signals the initiation of protein translation from mRNA when the AUG codon is in a Kozak consensus sequence. As a consequence, methionine is often incorporated into the N-terminal position of proteins in eukaryotes and archaea during translation, although it can be removed by post-translational modification. In bacteria, the derivative Nformylmethionine is used as the initial amino acid.

General Description

DL-Methionine is an essential amino acid containing sulphur. Methionine consists of an asymmetric carbon and exists as D (dextrogyre) and L (levogyre) optical isomers. The L-methionine is considered as biologically active. The racemic mixture of D and L-isomers forms DL-methionine, which is the commercially available methionine.

Safety Profile

Moderately toxic by ingestion and other routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. See also 1-METHIONINE.

Purification Methods

Crystallise it from hot water or EtOH. Also purify it by dissolving it in H2O and passing through an Amberlite IR-120 resin (NH4+ form). The eluate is concentrated and then passed through Amberlite IR-4B resin, and this eluate is evaporated to dryness. The residue is washed with EtOH, then Me2CO, dried and recrystallised from aqueous EtOH (colourless plates) [Baddiley & Jamieson J Chem Soc 4283 1954]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2125 1961, Beilstein 4 IV 3190.]

DL-Methionine Preparation Products And Raw materials

Raw materials

Acrolein Cupric acetate monohydrate Water Sodium cyanide METHYL MERCAPTAN
L-Methionine Ammonium bicarbonate
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Preparation Products

Zinc methionine sulfate Meprobamate D-Methionine (METHYLTHIO)ACETIC ACID N-(1-oxooctyl)-DL-methionine
N-(P-TOLUENESULFONYL)-D,L-METHIONINE 2-[(2,4-DICHLOROBENZOYL)AMINO]-4-(METHYLTHIO)BUTANOIC ACID 4-(METHYLTHIO)-2-[(PHENOXYACETYL)AMINO]BUTANOIC ACID 2-[(4-TERT-BUTYLBENZOYL)AMINO]-4-(METHYLTHIO)BUTANOIC ACID 2-(cyclopropylformamido)-4-(methylsulfanyl)butanoic Acid
DL-METHIONINE METHYLSULFONIUM BROMIDE, 99
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DL-Methionine Suppliers

Global( 922)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Chick Era Private Limited +919839569818 Uttar Pradesh, India 2 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Merck Ltd +91-2262109800 +91-2262109000 Maharashtra, India 272 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
Aditya Chemicals +91-9825237294 +91-9909971523 Gujarat, India 38 58 Inquiry
Suprim Chemicals +91-9324311273 +91-9029752732 Maharashtra, India 4 58 Inquiry
Prakash Chemicals Agencies +91-8511140657 Gujarat, India 106 58 Inquiry
Shreenath Chemicals +91-8369634120 +91-8369634120 Maharashtra, India 48 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
Medi Pharma Drug House +919930911911 Mumbai, India 143 58 Inquiry
Supplier Advantage
Chick Era Private Limited 58
HRV Global Life Sciences 58
Merck Ltd 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
Aditya Chemicals 58
Suprim Chemicals 58
Prakash Chemicals Agencies 58
Shreenath Chemicals 58
JSK Chemicals 58
Medi Pharma Drug House 58

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DL-Methionine≥ 99% (Titration) (RS)-Methionine Kochia fruit extract (10:1) DL-Met-OH DL-METHIONINE (13C5,D8,15N) DL-METHIONINE (METHYL-13C) Kochia seed extract BUFFER SOLUTION PH 4 AVS TITRINORM BOM BUFFER PH10 (20°C) AVS TITRINORM DL-Methionine Vetec(TM) reagent grade, 98% DL-Methionine(F DL-Methionine、AciMeti (n)-2-amino-4-(methylthio)butyric acid DL-Methionine,99% (S)-2-AMINO-4-(METHYLMERCAPTO)BUTYRIC ACID (S)-(+)-METHIONINE 2-AMINO-4(METHYLTHIO)BUTYRIC ACID 2-AMINO-4-METHYLMERCAPTOBUTYRIC ACID AKOS AUF2097 acimetion DL- MATHIONINE DL-METHIONINE FEED GRADE / POULTRY DL-Methoionine (+/-)-2-Amino-4-(methylthio)butyric acid~H-DL-Met-OH DL-METHIONINE FOR BIOCHEMISTRY Dl-MethionineForBiochemistry99+% DL-LETHIONINE DL-Methionine FCC DL-METHIONINE 98.5+% FCC DL-METHIONINE CELL CULTURE TESTED L-2-AMINO-4-(METHYLTHIO)BUTANOIC ACID L-2-AMINO-4-METHYLMERCAPTOBUTYRIC ACID Metion -Methylmercapto-aminobutyricacid Methionine dl-form Methionine (NF XIV) Methilonin Methilanin Mertionin Meonine (R,S)-2-Amino-4-methylsulfanyl-butyricacid (RS)-2-Amino-3-methylthiobutansαure Metione Neston Pedameth Petameth α-amino-γ-methylmercaptobutyricacid FEMA 3301 DL-2-AMINO-4-METHYLTHIOBUTANOIC ACID DL-2-AMINO-4-(METHYLTHIO)BUTYRIC ACID DL-BANTHIONINE DL-LOBAMINE DL-METHIONINE METHIONINE, L- METHIONINE, DL- L-LOBAMINE L-BANTHIONINE ACETYL-DL-METHIONINE, N-(P)