L-Serine
- CAS No.
- 56-45-1
- Chemical Name:
- L-Serine
- Synonyms
- SERINE;SER;L-RHAMNOSE MONOHYDRATE;H-SER-OH;L-SER;L-Serin;L-Ser-OH;L-(-)-SERINE;(s)-2-amino-3-hydroxypropanoicacid;8-HYDROXY-L-ALANINE
- CBNumber:
- CB5673304
- Molecular Formula:
- C3H7NO3
- Molecular Weight:
- 105.09
- MOL File:
- 56-45-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:15:30
| Melting point | 222 °C (dec.) (lit.) |
|---|---|
| Boiling point | 197.09°C (rough estimate) |
| alpha | 15.2 º (c=10, 2N HCl) |
| Density | 1.6 |
| refractive index | 1.4368 (estimate) |
| Flash point | 150°C |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| pka | 2.19(at 25℃) |
| color | White |
| PH | 5-6 (100g/l, H2O, 20℃) |
| Odor | wh. cryst. or cryst. powd., odorless, sweet taste |
| optical activity | [α]20/D +13.5±0.5°, c = 5% in 5 M HCl |
| Water Solubility | 250 g/L (20 ºC) |
| λmax |
λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.05 |
| Merck | 14,8460 |
| Sublimation | 150 ºC |
| BRN | 1721404 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | MTCFGRXMJLQNBG-REOHCLBHSA-N |
| LogP | -1.580 |
| CAS DataBase Reference | 56-45-1(CAS DataBase Reference) |
| NIST Chemistry Reference | L-Serine(56-45-1) |
| EPA Substance Registry System | L-Serine (56-45-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VT8100000 | |||||||||
| F | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29225000 | |||||||||
| Hazardous Substances Data | 56-45-1(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
L-Serine price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S4500 | L-Serine ReagentPlus?, ≥99% (HPLC) | 56-45-1 | 1G | ₹1820 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S4500 | L-Serine ReagentPlus?, ≥99% (HPLC) | 56-45-1 | 100G | ₹6650 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S4500 | L-Serine ReagentPlus?, ≥99% (HPLC) | 56-45-1 | 1KG | ₹44263.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S4311 | L-Serine from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0% | 56-45-1 | 25G | ₹5033.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S4311 | L-Serine from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0% | 56-45-1 | 100G | ₹8930.63 | 2022-06-14 | Buy |
L-Serine Chemical Properties,Uses,Production
Description
Serine (abbreviated as Ser or S) is an amino acid with the formula HO2CCH(NH2)CH2OH. It is one of the proteinogenic amino acids. Its codons in the genetic code are UCU, UCC, UCA, UCG, AGU and AGC. By virtue of the hydroxyl group, serine is classified as a polar amino acid.
L-serine is an amino acid essential for the synthesis of phosphatidylserine, which is a component of the membrane of brain cells (i.e., neurons). It can be produced in the body, including the brain, but an external supply from the diet is essential in maintaining necessary levels. Although preclinical studies suggest L-serine may inhibit inflammation in the brain, levels of L-serine in humans do not appear to be associated with dementia or cognitive decline. Because L-serine is a naturally occurring amino acid, supplementation is likely safe in moderation.
Chemical Properties
L-Serine is a white crystal or crystalline powder, slightly sweet taste, soluble in water and acid, insoluble in alcohol and ether. From soybeans, wine fermentation agent, dairy products, eggs, fish, lactalbumin, meat, nuts, seafood, whey, and whole grains to get. Serine is also used as a dietary supplement where it can aid improved memory function and in personal care products where it helps with the production of new skin cells.
Uses
L-Serine has been used in the preparation of Tris-BSAN buffer for homogenization. It has also been used for quantitative analysis of excretion of polypeptides in normal urine.
Production Methods
Industrially , L - serine is produced by fermentation, with an estimated 100 - 1000 tonnes per year produced . In the laboratory, racemic serine can be prepared from methyl acrylate via several steps.
Definition
ChEBI: L-serine is the L-enantiomer of serine. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a serine family amino acid, a proteinogenic amino acid, a L-alpha-amino acid and a serine. It is a conjugate base of a L-serinium. It is a conjugate acid of a L-serinate. It is an enantiomer of a D-serine. It is a tautomer of a L-serine zwitterion.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biological Activity
L-Serine is an endogenous agonist at the inhibitory glycine receptor.
L-Serine is a non-essential amino acid that acts as a precursor for nucleotide synthesis. It has roles in the development and function of the central nervous system. L-Serine also has a role in cellular proliferation.
Precursor of glycine by serine hydroxymethyltransferase.
Safety
L-serine is generally safe to take as an oral dietary supplement. In a phase 1 safety trial in 20 ALS patients, L-serine treatment (0.5-15.0 g, twice daily) for 6 months was generally well-tolerated and appeared to be safe. Two patients withdrew from the trial due to gastrointestinal side effects but no other adverse events or changes in routine blood tests measures were observed.
Purification Methods
A likely impurity is glycine. Crystallise L-serine from H2O by adding 4volumes of EtOH. Dry and store it in a desiccator. It sublimes at 160-170o/0.3mm with 99.7% recovery, and unracemised [Gross & Gradsky J Am
L-Serine Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3753 | 58 | Inquiry |
| AMINO ORGANICS | +919866989891 | Hyderabad, India | 273 | 58 | Inquiry |
| Dodhia Group | +91-9619867345 +91-9619867345 | Mumbai, India | 129 | 58 | Inquiry |
| Innovative Labs | +91-9885794886 +91-9885794886 | Telangana, India | 219 | 58 | Inquiry |
| SS Reagents and Chemicals | +91-7981238883 +91-7981238883 | Hyderabad, India | 404 | 58 | Inquiry |
| ARRAKIS INDUSTRIES LLP | +91 74995 32711 | Maharashtra, India | 1353 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3075 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6157 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| AMINO ORGANICS | 58 |
| Dodhia Group | 58 |
| Innovative Labs | 58 |
| SS Reagents and Chemicals | 58 |
| ARRAKIS INDUSTRIES LLP | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| SynZeal Research Pvt Ltd | 58 |
| LOBA CHEMIE PVT.LTD. | 58 |
| Central Drug House(P) Ltd. | 58 |
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