Lidocaine hydrochloride
- CAS No.
- 6108-05-0
- Chemical Name:
- Lidocaine hydrochloride
- Synonyms
- LINOCAINE HCL;Linocaine hydrochlor;Linocaine hydrochloride(lidocaine HCL);2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate;ACETAMIDE,2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)-MONOHYDROCHLORIDE, MONOHYDRATE;dolicaine;Lidocaine HC1;Lidocaine HCl USP;N-Oxide Lidocaine-d;LIDOCAINE HCL HYDRATE
- CBNumber:
- CB4486868
- Molecular Formula:
- C14H25ClN2O2
- Molecular Weight:
- 288.82
- MOL File:
- 6108-05-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/31 13:51:23
| Melting point | 75-79℃ |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | solid |
| color | white |
| Water Solubility | Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether. |
| InChI | InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2 |
| InChIKey | YECIFGHRMFEPJK-UHFFFAOYSA-N |
| SMILES | C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl |
| LogP | 2.359 (est) |
| CAS DataBase Reference | 6108-05-0(CAS DataBase Reference) |
Lidocaine hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1257 | Lidocaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 6108-05-0 | 500MG | ₹8042.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1257 | Lidocaine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 6108-05-0 | 5G | ₹50628.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L5647 | Lidocaine hydrochloride monohydrate solid | 6108-05-0 | 15G | ₹10045.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L5647 | Lidocaine hydrochloride monohydrate solid | 6108-05-0 | 100G | ₹14050.85 | 2022-06-14 | Buy |
Lidocaine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.
Uses
Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Definition
ChEBI: Linocaine hydrochloride is the monohydrate form of lidocaine hydrochloride. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of Procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Application
Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.
Contact allergens
Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.
Synthesis
A method for preparing Lidocaine hydrochloride is described as follows. The method comprises the following steps: by taking 2,6-xylenol as a raw material, Pd/C as a primary catalyst and 2,6-dimethylcyclohexanone as a promoter, performing liquid phase amination with ammonia water at high temperature, thereby obtaining a midbody 2,6-dimethylaniline; enabling sodium methylate, 2,6-dimethylaniline and N,N-lignocaine methyl acetate as raw materials to react at 90-95 DEGC, distilling while reaction is performed to remove methanol till no methanol can be evaporated out, continuously reacting for 30 minutes, cooling to the room temperature, adding dichloroethane, washing with water, and leaving to stand to layer, thereby obtaining an organic layer, namely, a lidocaine based dichloroethane solution; further adding hydrochloric acid into the lidocaine based dichloroethane solution, adjusting the pH value to be 3.5-4 by using hydrogen chloride, adding activated carbon to reflux for 20-40 minutes, filtering, concentrating the filtrate, cooling, crystallizing, and dying, thereby obtaining Lidocaine hydrochloride.
Mode of action
Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.
Lidocaine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Alex Pharmachem Pvt. Ltd | +91-9825015135 +91-9974615135 | Gujarat, India | 10 | 58 | Inquiry |
| Mahendra Chemicals | +91-8511204451 +91-9824019625 | Gujarat, India | 7 | 58 | Inquiry |
| Meck Pharmaceuticals and Chemicals Pvt. Ltd. | +91-9898053709 +91-9898540709 | Gujarat, India | 44 | 58 | Inquiry |
| Chemino Pharma Ltd | +91-8689897373 +91-8689897373 | Maharashtra, India | 31 | 58 | Inquiry |
| Technodrugs Intermediates Pvt. Ltd. | +91-2226743405 +91-2226743405 | Maharashtra, India | 16 | 58 | Inquiry |
| Apex Healthcare Limited | +9199825711244 | Gujarat, India | 22 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Chemixl Aromatiq Pvt Ltd | +91-9824173530 +91-9687606466 | Gujarat, India | 16 | 58 | Inquiry |
| Suyog Life Sciences Pvt. Ltd. | 91-2646-252211 | Gujarat, India | 25 | 58 | Inquiry |
Related articles
- Usage and Application of Linocaine hydrochloride
- Lidocaine hydrochloride is a medium effect amides local anesthetic used as a local anesthetic and antiarrhythmic drug
- Aug 11，2022
Related Qustion
- Q:What is the difference between Lidocaine and Lidocaine Hydrochloride?
- A:Lidocaine Hydrochloride USP Monohydrate binds more readily to sodium channels in an activated state.
- Sep 9，2024