Lidocaine hydrochloride
- CAS No.
- 73-78-9
- Chemical Name:
- Lidocaine hydrochloride
- Synonyms
- LIDOCAINE HCL;LIGNOCAINE HYDROCHLORIDE;Lidocaine HCI;rucainahydrochloride;duncainehydrochloride;gravocainhydrochloride;leostesinhydrochloride;xylocitinhydrochloride;2-diethylamino-2’,6’-acetoxylididehydrochloride;alpha-diethylamino-2,6-acetoxylidinehydrochloride
- CBNumber:
- CB4117973
- Molecular Formula:
- C14H23ClN2O
- Molecular Weight:
- 270.8
- MOL File:
- 73-78-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:07
| Melting point | 80-82°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| form | Solid |
| color | White to off-white |
| Water Solubility | Water : ≥ 36 mg/mL (132.94 mM) |
| InChI | InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H |
| InChIKey | IYBQHJMYDGVZRY-UHFFFAOYSA-N |
| SMILES | C(NC1=C(C)C=CC=C1C)(=O)CN(CC)CC.[H]Cl |
| LogP | 2.359 (est) |
| CAS DataBase Reference | 73-78-9(CAS DataBase Reference) |
| EPA Substance Registry System | Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride (73-78-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 oral in mouse: 220mg/kg |
Lidocaine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.
Definition
ChEBI: Lidocaine hydrochloride is the anhydrous form of the hydrochloride salt of lidocaine. It functions as both a local anesthetic and cardiac depressant, and is commonly used as an antiarrhythmic agent. Its potency is higher and its effects last longer than those of procaine, but its duration of action is shorter than that of bupivacaine or prilocaine.
Biological Functions
Lidocaine hydrochloride (Xylocaine) is the most commonly used local anesthetic. It is well tolerated, and in addition to its use in infiltration and regional nerve blocks, it is commonly used for spinal and topical anesthesia and as an antiarrhythmic agent. Lidocaine has a more rapidly occurring, more intense, and more prolonged duration of action than does procaine.
General Description
Lidocaine hydrochloride,2-(diethylamino)-2 ,6 -acetoxylidide monohydrochloride(Xylocaine), was conceived as a derivative of gramine(3-dimethylaminomethylindole) and introduced as a localanesthetic. It is now being used intravenously as a standardparenteral agent for suppression of arrhythmias associatedwith acute myocardial infarction and cardiac surgery.It isthe drug of choice for the parenteral treatment of prematureventricular contractions.
Mechanism of action
Lidocaine can block Na+ and K+ ion channels and regulate intracellular and extracellular calcium concentrations through other ligand-gated ion channels. Lidocaine was the first sodium channel blocker to be identified. Its main mechanism of action is blocking voltage-gated Na+ channels (VGSC/NaVs).
Clinical Use
Lidocaine hydrochloride is a class IB antiarrhythmicagent with a different effect on the electrophysiologicalproperties of myocardial cells from that of procainamideand quinidine. It binds with equal affinity to the active (A)and inactive (I) Na+ ion channels. It depresses diastolic depolarizationand automaticity in the Purkinje fiber networkand increases the functional refractory period relative toaction potential duration, as do procainamide and quinidine.It differs from the latter two drugs, however, in that it doesnot decrease, and may even enhance, conduction velocity and increase membrane responsiveness to stimulation.There are fewer data available on the subcellular mechanismsresponsible for the antiarrhythmic actions of lidocainethan on the more established drug quinidine. It has been proposedthat lidocaine has little effect on membrane cation exchangeof the atria. Sodium ion entrance into ventricularcells during excitation is not influenced by lidocaine becauseit does not alter conduction velocity in this area.Lidocaine hydrochloride does depress Na+ influx duringdiastole, as do all other antiarrhythmic drugs, to diminishautomaticity in myocardial tissue. It also alters membraneresponsiveness in Purkinje fibers, allowing increased conductionvelocity and ample membrane potential at the timeof excitation.
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, subcutaneous, intramuscular, and intratracheal routes. Human systemic effects: somnolence, respiratory depression, low blood pressure, cardiomyopathy includmg infarction, pulse rate increase. An experimental teratogen. Other experimental reproductive effects. A skin and eye irritant. An anesthetic. When heated to decomposition it emits very toxic fumes of NOx and HCl.
storage
Store in a tightly closed container at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze. Keep all medications away from children and pets.
Lidocaine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shree Ganesh Dye Chem | +91 079-26872726 | Gujarat, India | 97 | 58 | Inquiry |
| NILKANTH HEALTH CHEM (I) PRIVATE LIMITED | +91 8000452862 | Gujarat, India | 17 | 58 | Inquiry |
| NB Healthcare Pvt Ltd | +91 7227055467 | Gujarat, India | 37 | 58 | Inquiry |
| THE MOLECULEZ | +91-7506703683 +91-7506703683 | Maharashtra, India | 79 | 58 | Inquiry |
| AVD pharmaceuticals Pvt Ltd | +919860835260 | Pune, India | 102 | 58 | Inquiry |
| Unilab Company | +91-912228260263 +91-63917864522 | Tamil Nadu, India | 43 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Chynops Pharma | +919998000404 | Gujarat, India | 39 | 58 | Inquiry |
| SKVNTTR LIFE SCIENCE LLP | +91-9825953518 +91-9825953518 | Gujarat, India | 9 | 58 | Inquiry |
| Dishman Carbogen Amcis Ltd (Dishman Group) | +91-2717420100 +91-8154017093 | Gujarat, India | 90 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Shree Ganesh Dye Chem | 58 |
| NILKANTH HEALTH CHEM (I) PRIVATE LIMITED | 58 |
| NB Healthcare Pvt Ltd | 58 |
| THE MOLECULEZ | 58 |
| AVD pharmaceuticals Pvt Ltd | 58 |
| Unilab Company | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Chynops Pharma | 58 |
| SKVNTTR LIFE SCIENCE LLP | 58 |
| Dishman Carbogen Amcis Ltd (Dishman Group) | 58 |
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