QX 314 chloride
- CAS No.
- 5369-03-9
- Chemical Name:
- QX 314 chloride
- Synonyms
- QX314.Cl;QX 314 CHLORIDE;N-Ethyllidocaine chloride;Lidocaine N-ethyl chloride;QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride
- CBNumber:
- CB1191994
- Molecular Formula:
- C16H27ClN2O
- Molecular Weight:
- 298.85
- MOL File:
- 5369-03-9.mol
- Modify Date:
- 2023/9/20 16:43:00
QX 314 chloride price More Price(2)
QX 314 chloride Chemical Properties,Uses,Production
Uses
QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
Biological Activity
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.
Biochem/physiol Actions
Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.
QX 314 chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24722 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48467 | 58 | Inquiry |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | China | 2031 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8739 | 58 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry |