QX 314 chloride
QX 314 chloride
- CAS:
- 5369-03-9
- MF:
- C16H27ClN2O
- MW:
- 298.85
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Company Type
Properties
- Melting point:
- 209-211 °C
- storage temp.
- Room temp
- solubility
- insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O
- form
- solid
- color
- White
- Water Solubility
- Soluble in water (100mM)
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Use
QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
0 India supplier list of "QX 314 chloride"
- Product Name:LidocaineN-ethylchloride
- Products Intro:Brand:sigma aldrich | Product Number:L1663
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:QX-314 chloride
- Products Intro:Purity: 98.00% | Package: 10 mg;100 mg;25 mg;5 mg;50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:QX 314 chloride
- Products Intro:Purity: 99.0% Min | Package: 1g;1.1USD
- Company Type: Trader
- Country/Region: CHINA
$1.10/ 1g
- Product Name:QX-314 chloride (N-Ethyllidocaine chloride)
- Products Intro:Purity: 98% | Package: $23.9/10mg;$98.9/50mg;$157.9/100mg;$355.9/250mg;$639.9/500mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies