QX 314 chloride
QX 314 chloride
- CAS:
- 5369-03-9
- MF:
- C16H27ClN2O
- MW:
- 298.85
Suppliers by country/region
Company Type
Properties
- Melting point:
- 209-211 °C
- storage temp.
- Room temp
- solubility
- insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O
- form
- solid
- color
- White
- Water Solubility
- Soluble in water (100mM)
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Use
QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
0 India supplier list of "QX 314 chloride"
- Product Name:LidocaineN-ethylchloride
- Products Intro:Brand:sigma aldrich | Product Number:L1663
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride
- Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:QX 314 chloride
- Products Intro:Purity: 99.0% Min | Package: 1g;1.1USD
- Company Type: Trader
- Country/Region: CHINA
$1.10/ 1g
- Product Name:QX-314 chloride (N-Ethyllidocaine chloride)
- Products Intro:Purity: 98% | Package: $23.9/10mg;$98.9/50mg;$157.9/100mg;$355.9/250mg;$639.9/500mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:QX-314 chloride (N-Ethyllidocaine chloride)
- Products Intro:Purity: >=99% | Package: $130.9/ml;Bulk package | CustNote: 99%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
-
50 mg$99.00
- Product Name:QX-314 (chloride)
- Products Intro:Brand: Caymanchem | Product Number: 18454 | Purity: ≥98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: cof,mof
-
50 mg$129.00
- Product Name:N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
- Products Intro:Brand: Tocris Bioscience | Product Number: 2313 | Purity: ≥99% (HPLC)
- Company Type: Trader
- Country/Region: UNITED KINGDOM
- Main Products: cof,mof
- Product Name:QX314chloride
- Products Intro:Brand：dcchemicals | Product Number：DC26095 | Purity：>98%
- Company Type: Trader
- Country/Region: UNITED STATES
-
5mg$90.0010mg$150.00
- Product Name:QX-314(chloride)
- Products Intro:Brand：ChemScene | Product Number：CS-0029028 | Purity：99.83%
- Company Type: Trader
- Country/Region: UNITED STATES
-
50mg$195.00
- Products Intro:Brand:1pchem | Product Number:1P00DG65 | Purity:99%
- Company Type: Trader
- Country/Region: UNITED STATES