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QX 314 chloride

QX 314 chloride Structure
QX 314 chloride structure
CAS No.
5369-03-9
Chemical Name:
QX 314 chloride
Synonyms
QX314.Cl;QX 314 CHLORIDE;N-Ethyllidocaine chloride;Lidocaine N-ethyl chloride;QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride
CBNumber:
CB1191994
Molecular Formula:
C16H27ClN2O
Molecular Weight:
298.85
MDL Number:
MFCD01669894
MOL File:
5369-03-9.mol
Last updated:2024-11-20 11:41:24
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QX 314 chloride Properties

Melting point 209-211 °C
storage temp. Room temp
solubility insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O
form solid
color White
Water Solubility Soluble in water (100mM)

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

QX 314 chloride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L1663 Lidocaine N-ethyl chloride 5369-03-9 500MG $315 2023-06-20 Buy
Sigma-Aldrich L1663 Lidocaine N-ethyl chloride 5369-03-9 1G $579 2023-06-20 Buy
Cayman Chemical 18454 QX-314 (chloride) ≥98% 5369-03-9 50mg $121 2024-03-01 Buy
Tocris 2313 QX314chloride ≥99%(HPLC) 5369-03-9 50 $139 2021-12-16 Buy
TRC Q950010 QX314Chloride 5369-03-9 50mg $130 2021-12-16 Buy
Product number Packaging Price Buy
L1663 500MG $315 Buy
L1663 1G $579 Buy
18454 50mg $121 Buy
2313 50 $139 Buy
Q950010 50mg $130 Buy

QX 314 chloride Chemical Properties,Uses,Production

Uses

QX 314 Chloride has been shown to have antitussive properties in mammalian animal models.

Uses

QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.

Biochem/physiol Actions

Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.

storage

Room temperature

QX 314 chloride Preparation Products And Raw materials

Raw materials

Preparation Products

QX 314 chloride Suppliers

Global( 52)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Shanghai Universal Biotech Co.,Ltd 13774214275 zhouzz@univ-bio.com China 24991 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216 info@yuhaochemical.com China 9387 52
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Aladdin Scientific 		58
Shanghai Universal Biotech Co.,Ltd 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Ascent Scientific 60
Hangzhou Yuhao Chemical Technology Co., Ltd 52

View Lastest Price from QX 314 chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
QX-314 chloride pictures 2024-11-19 QX-314 chloride
5369-03-9
 US $132.00-48.00 / mg 99.73% 10g TargetMol Chemicals Inc.
QX-314 chloride pictures 2024-11-19 QX-314 chloride
5369-03-9
 US $132.00-48.00 / mg 99.73% 10g TargetMol Chemicals Inc.
QX 314 chloride pictures 2022-05-13 QX 314 chloride
5369-03-9
 US $1.10 / g 1g 99.0% Min 100 Tons Dideu Industries Group Limited
  • QX-314 chloride pictures
  • QX-314 chloride
    5369-03-9
  • US $132.00-48.00 / mg
  • 99.73%
  • TargetMol Chemicals Inc.
  • QX-314 chloride pictures
  • QX-314 chloride
    5369-03-9
  • US $132.00-48.00 / mg
  • 99.73%
  • TargetMol Chemicals Inc.
  • QX 314 chloride pictures
  • QX 314 chloride
    5369-03-9
  • US $1.10 / g
  • 99.0% Min
  • Dideu Industries Group Limited

QX 314 chloride Spectrum

QX 314 chloride(5369-03-9)MSQX 314 chloride(5369-03-9)1HNMR

5369-03-9(QX 314 chloride)Related Search:

Sulfanilamide QX-314 Linocaine hydrochloride QX 314 chloride 2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIMETHYL-2-OXOETHANAMINIUM CL
QX 314 CHLORIDE N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE QX314.Cl 2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride [2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride [2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride Lidocaine N-ethyl chloride N-Ethyllidocaine chloride QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE Inhibitor,calcium,Sodium Channel,QX314 chloride,channel,Na channels,QX314,sodium,Na+ channels,QX-314,inhibit,QX 314 chloride,QX 314 5369-03-9 5369-3-9 C16H27N2OCl Cell Signaling and Neuroscience Cell Biology BioChemical Other Sodium Channel Modulators Monovalent Ion Channels Ion Channels Voltage-gated Ion Channels Sodium Channel Modulators Ion Channels