A 967079
- CAS No.
- 1170613-55-4
- Chemical Name:
- A 967079
- Synonyms
- A 967079;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079
- CBNumber:
- CB22650391
- Molecular Formula:
- C12H14FNO
- Molecular Weight:
- 207.24
- MOL File:
- 1170613-55-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/7 11:09:01
| Boiling point | 324.4±34.0 °C(Predicted) |
|---|---|
| Density | 1.03±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥12mg/mL |
| pka | 12.23±0.40(Predicted) |
| form | powder |
| color | white to tan |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
| InChI | InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+ |
| InChIKey | HKROEBDHHKMNBZ-CHBKHGQFSA-N |
| SMILES | C(/C1=CC=C(F)C=C1)=C(/C)\C(=N\O)\CC |
A 967079 price More Price(2)
A 967079 Chemical Properties,Uses,Production
Uses
(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.
General Description
A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.
Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.
A 967079 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hubei Chuchang Biotech Co., Ltd. | +undefined15623860702 | China | 111 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | United States | 19639 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| Hubei Chuchang Biotech Co., Ltd. | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| Alfa Chemistry | 58 |
| InvivoChem | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aceschem Inc. | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | 58 |