ChemicalBook > Product Catalog >Biochemical Engineering >Protein Research >Protease inhibitors >LACTACYSTIN
LACTACYSTIN
- CAS No.
- 133343-34-7
- Chemical Name:
- LACTACYSTIN
- Synonyms
- Lacta;Aids008388;LACTACYSTIN;Aids-008388;(+)-LACTACYSTIN;LACTACYSTIN (NATIVE);LACTACYSTIN USP/EP/BP;LACTACYSTIN, SYNTHETIC;LACTACYSTIN, STREPTOMYCES SP;Lactacystin, proteasome inhibitor
- CBNumber:
- CB5136696
- Molecular Formula:
- C15H24N2O7S
- Molecular Weight:
- 376.43
- MOL File:
- 133343-34-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 233-235°C dec. |
|---|---|
| Boiling point | 714.9±60.0 °C(Predicted) |
| Density | 1.367±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 20 mg/ml), in Water (up to 10 mg/ml), or in Ethanol (up to 1 mg/ml). |
| form | powder |
| pka | 3.11±0.10(Predicted) |
| color | White to off-white |
| Water Solubility | Soluble to 10 mM in water |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used with one working day. Aqueous solutions should not be stored. |
LACTACYSTIN Chemical Properties,Uses,Production
Description
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 μM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.
Chemical Properties
White Powder
Uses
Lactacystin has been used:
- as a proteasome inhibitor to inhibit protein degradation
- to inhibit proteasomal activity of cells for live cell imaging
- to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
- to provide unilateral injection to animals to induce nigrostriatal lesions
Definition
ChEBI: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.
General Description
Lactacystin is an antibiotic?and a metabolite of Streptomyces?spp.
LACTACYSTIN Preparation Products And Raw materials
Raw materials
Preparation Products
LACTACYSTIN Suppliers
Global( 136)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| VIVAN Life Sciences Pvt. Limited. | +91(22) 2544 4584 / 2544 4585 | New Delhi, India | 138 | 50 | Inquiry |
| CRO Splendid Lab Private Limited | 08048371921Ext 950 | Pune, India | 5 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32159 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22854 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8467 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | China | 33338 | 58 | Inquiry |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | China | 40066 | 58 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9803 | 58 | Inquiry |
133343-34-7(LACTACYSTIN)Related Search:
CLASTO-LACTACYSTIN,Clasto-lactacystin -Lactone, Omuralide,Clasto-lactacystin b-Lactone, Omuralide,CLASTO-LACTACYSTIN B-LACTONE
MG-132
(+)-LACTACYSTIN ALLYL ESTER,LACTACYSTIN ALLYL ESTER
MG-115
N-PROPYL 3-MERCAPTOPROPIONATE
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(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBOXY-N-ACETYL-L-CYSTEINE THIOESTER
3S-HYDROXY-2R-(1-HYDROXY-2-METHYLPROPYL)-4R-METHYL-5-OXO-2-PYRROLIDINECARBOXYLATE-N-ACETYL-L-CYSTEINE
(+)-LACTACYSTIN
LACTACYSTIN
LACTACYSTIN (NATIVE)
LACTACYSTIN, STREPTOMYCES SP
LACTACYSTIN, SYNTHETIC
N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE
(2R)-2-(Acetylamino)-3-[[(2R)-3β-hydroxy-4β-methyl-2-[(S)-1-hydroxy-2-methylpropyl]-5-oxopyrrolidine-2-yl]carbonylthio]propanoic acid
(2R)-2-(Acetylamino)-3-[[[(2R,3S,4R)-2-[(1S)-2-methyl-1-hydroxypropyl]-3-hydroxy-4-methyl-5-oxopyrrolidin-2-yl]carbonyl]thio]propionic acid
S-[2R,3S,4R]-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYROLIDINECARBONYL
Aids008388
Aids-008388
L-Cysteine, N-acetyl-, (2R,3S,4R)-3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinecarboxylate (ester)
N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-Methylpropyl]-4-Methyl-5-oxo-D-prolyl]-L-cysteine
Lacta
LACTACYSTIN USP/EP/BP
L-Cysteine, N-acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-
Lactacystin, proteasome inhibitor
133343-34-7
C15H24N2O7S
Biochemicals and Reagents
BioChemical
Enzyme Inhibitors
Enzyme Inhibitors by Enzyme
Enzymes, Inhibitors, and Substrates
Proteasome inhibitor
P to Q
All Inhibitors
Inhibitors
Metabolites
Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases
InhibitorsProtease Inhibitors
Intracellular Protein Degradation
Nitric Oxide and Cell Stress
P to
Protease Inhibitor Specificity Index
Proteasome inhibitor
Proteasome inhibitorEnzyme Inhibitors by Enzyme
Proteasomes
Protease
ProteaseInhibitors