CLASTO-LACTACYSTIN BETA-LACTONE
- CAS No.
- 154226-60-5
- Chemical Name:
- CLASTO-LACTACYSTIN BETA-LACTONE
- Synonyms
- OMURALIDE;BETA-CLASTOLACTACYSTIN;Clasto-Lactacystin β-lactone;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);CLASTO-LACTACYSTIN BETA-LACTONE;LACTACYSTIN, CLASTO-, BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione;6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
- CBNumber:
- CB9352564
- Molecular Formula:
- C10H15NO4
- Molecular Weight:
- 213.23
- MOL File:
- 154226-60-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 20/21/22-37/38-41-36/37/38-25 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| NFPA 704 |
|
CLASTO-LACTACYSTIN BETA-LACTONE price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L7035 | clasto-Lactacystin β-lactone | 154226-60-5 | 0.1MG | ₹43451.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 426102 | clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. | 154226-60-5 | 100μG | ₹33440 | 2022-06-14 | Buy |
CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
Biochem/physiol Actions
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.
CLASTO-LACTACYSTIN BETA-LACTONE Preparation Products And Raw materials
Raw materials
Preparation Products
CLASTO-LACTACYSTIN BETA-LACTONE Suppliers
Global( 59)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| DC Chemicals | 021-58447131 13564518121 | China | 9412 | 58 | Inquiry |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |
| Beijing Lebo Biotechnology Co., Ltd. | 010-50934026 | CHINA | 6057 | 58 | Inquiry |
| Shanghai Hao Biological Technology Co., Ltd. | 021-58116080 18019263206 | CHINA | 6921 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9707 | 58 | Inquiry |
| Toronto Research Chemicals | +1 (416) 665-9696 | Canada | 6088 | 71 | Inquiry |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | China | 96815 | 76 | Inquiry |
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OMURALIDE
LACTACYSTIN, CLASTO-, BETA-LACTONE
BETA-CLASTOLACTACYSTIN
CLASTO-LACTACYSTIN BETA-LACTONE
1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
clasto-lactacystin β-lactone
Clasto-lactacystin
(OMuralide)
(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
Clasto-Lactacystin β-lactone
154226-60-5
Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases
InhibitorsProtease Inhibitors
Proteasome inhibitor
Proteasome inhibitorEnzyme Inhibitors by Enzyme
Intracellular Protein Degradation
Nitric Oxide and Cell Stress
P to
Protease Inhibitor Specificity Index
Proteasomes
ProteasomeInhibitors
Inhibitors