CLASTO-LACTACYSTIN BETA-LACTONE
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- ₹33440 - ₹43451.55
- Product name: CLASTO-LACTACYSTIN BETA-LACTONE
- CAS: 154226-60-5
- MF: C10H15NO4
- MW: 213.23
- EINECS:
- MDL Number:MFCD01076526
- Synonyms:OMURALIDE;LACTACYSTIN, CLASTO-, BETA-LACTONE;BETA-CLASTOLACTACYSTIN;CLASTO-LACTACYSTIN BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 0.1MG
- 100μG
- ManufacturerSigma-Aldrich(India)
- Product number426102
- Product descriptionclasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor.
- Packaging100μG
- Price₹33440
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberL7035
- Product descriptionclasto-Lactacystin β-lactone
- Packaging0.1MG
- Price₹43451.55
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 426102 | clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. | 100μG | ₹33440 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L7035 | clasto-Lactacystin β-lactone | 0.1MG | ₹43451.55 | 2022-06-14 | Buy |
Properties
Melting point :186-187°C
storage temp. :-20°C
solubility :DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
form :White solid
color :White
storage temp. :-20°C
solubility :DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
form :White solid
color :White
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Lactacystin is a microbial metabolite isolated from Streptomyces which is now widely used as a selective inhibitor of the 20S proteasome. Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. Both lactacystin and its β-lactone metabolite induce differentiation and inhibit cell cycle progression in several tumor cell lines. Clasto-lactacystin β-lactone irreversibly alkylates subunit X of the 20S proteasome. It is at least 10 times more active than the parent compound; this increased activity may be a function of increased cell permeability. Inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of clasto-lactacystin β-lactone are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.More related product prices
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