MG-115

MG-115 Structure
CAS No.
133407-86-0
Chemical Name:
MG-115
Synonyms
MG-115;Z-LLnV;(S)-MG115;Z-LL-NVA-CHO;MG115, Z-LLnV;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;z-leu-leu-norvalinal;Z-LEU-LEU-NVA-ALDEHYDE;MG-115 (DMSO solution)
CBNumber:
CB0195607
Molecular Formula:
C25H39N3O5
Molecular Weight:
461.59
MOL File:
133407-86-0.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:50:00

MG-115 Properties

Boiling point 678.8±55.0 °C(Predicted)
Density 1.082±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble
form powder
pka 11.14±0.46(Predicted)
color white

SAFETY

Risk and Safety Statements

WGK Germany  3

MG-115 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C6706 Z-Leu-Leu-Norvalinal ≥90% (HPLC), powder 133407-86-0 1MG ₹5596.53 2022-06-14 Buy
Sigma-Aldrich(India) C6706 Z-Leu-Leu-Norvalinal ≥90% (HPLC), powder 133407-86-0 5MG ₹15566.35 2022-06-14 Buy
Sigma-Aldrich(India) 474780 MG-115 - CAS 133407-86-0 - Calbiochem Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). 133407-86-0 5MG ₹21460 2022-06-14 Buy
Product number Packaging Price Buy
C6706 1MG ₹5596.53 Buy
C6706 5MG ₹15566.35 Buy
474780 5MG ₹21460 Buy

MG-115 Chemical Properties,Uses,Production

Description

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

Uses

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

General Description

Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

MG-115 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 88)Suppliers
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RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703 China 6213 58 Inquiry
PROTEASOME INHIBITOR MG-115 N-CBZ-LEU-LEU-NORVALINAL MG-115 Z-LL-NVA-CHO Z-LEU-LEU-NVA-ALDEHYDE Z-LEU-LEU-NVA-CHO Z-LEU-LEU-NVA-H Z-LEU-LEU-NVA-H (ALDEHYDE) CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-NORVALINAL CARBOBENZOXY-L-LEUCYL-L-LEUCYL-NORVALINAL BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-NORVALINAL z-leu-leu-norvalinal N-carbobenzyloxy-Leu-Leu-norvalinal MG115, Z-LLnV Z-Leu-Leu-Norvalinal,MG115, Z-LLnV (S)-MG115 Z-LLnV L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]- MG-115 - CAS 133407-86-0 - Calbiochem MG-115 (DMSO solution) 133407-86-0 C25H39N3O5 Inhibitors BioChemical Biochemicals and Reagents Application Index Cell Signaling Enzymes Proteasome, Calpain and Lysosomal Proteases Proteasomes Enzymes, Inhibitors, and Substrates Calpain and Lysosomal Proteases Proteasome Inhibitors Aldehydes and Substrates Application Index Bioactive Small Molecules Biochemicals and Reagents Building Blocks C13-C60 Calpain and Proteasome Inhibitors Carbonyl Compounds Cell Biology Cell Signaling and Neuroscience Cell Signaling Enzymes Chemical Synthesis Endoplasmic Reticulum Stress Enzymes Inhibitors Intracellular Protein Degradation Nitric Oxide and Cell Stress Organic Building Blocks Proteasome Proteasomes Z ProteasomeInhibitors peptides