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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Proteases >Gamma-secretase inhibitors >DIBENZAZEPINE

DIBENZAZEPINE

DIBENZAZEPINE Structure
CAS No.
209984-56-5
Chemical Name:
DIBENZAZEPINE
Synonyms
GSI-XX;CS-366;YO01027;DIBENZAZEPINE;Deshydroxy LY-411575;6-Chloro-α-Tetralone;YO-01027, 10 mM in DMSO;γ-Secretase Inhibitor XX;YO-01027 (Dibenzazepine);Dibenzazepine (YO-01027)
CBNumber:
CB11234300
Molecular Formula:
C26H23F2N3O3
Molecular Weight:
463.48
MOL File:
209984-56-5.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

DIBENZAZEPINE Properties

Melting point 257-259?C
Boiling point 801.3±65.0 °C(Predicted)
Density 1.35
storage temp. -20°C
solubility DMSO: soluble15mg/mL, clear
pka 12.76±0.20(Predicted)
form White solid
color white to beige
optical activity [α]/D -128.0 to -154.0°-0.25 in methanol
InChIKey QSHGISMANBKLQL-OWJWWREXSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
HS Code  29337900
NFPA 704
0
2 0

DIBENZAZEPINE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0649 Deshydroxy LY-411575 ≥98% (HPLC) 209984-56-5 5MG ₹11506.98 2022-06-14 Buy
Sigma-Aldrich(India) SML0649 Deshydroxy LY-411575 ≥98% (HPLC) 209984-56-5 25MG ₹46374.3 2022-06-14 Buy
Sigma-Aldrich(India) 565789 γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg257 209984-56-5 500μG ₹29850 2022-06-14 Buy
Sigma-Aldrich(India) 565789 γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg257 209984-56-5 1MG ₹37040 2022-06-14 Buy
Product number Packaging Price Buy
SML0649 5MG ₹11506.98 Buy
SML0649 25MG ₹46374.3 Buy
565789 500μG ₹29850 Buy
565789 1MG ₹37040 Buy

DIBENZAZEPINE Chemical Properties,Uses,Production

Description

γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC50 = 1.7 nM). Within 4 hours after a single 100 μM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of Aβ40 by reducing Aβ40 levels by 71%.

Chemical Properties

White Solid

Uses

DIBENZAZEPINE is a dipeptidic-secretase inhibitor and a antiAlzheimer agent.

General Description

A cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 μmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 μmol/kg, i.p).

DIBENZAZEPINE Preparation Products And Raw materials

Raw materials

Preparation Products

DIBENZAZEPINE Suppliers

Global( 156)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29808 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32202 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
Nextpeptide Inc +86-0571-81612335 +8613336028439 China 19908 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3135 58 Inquiry
TargetMol Chemicals Inc. United States 38636 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Nextpeptide Inc 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58

DIBENZAZEPINE Spectrum

DIBENZAZEPINE(209984-56-5)1HNMR

209984-56-5(DIBENZAZEPINE)Related Search:

BETA-SECRETASE INHIBITOR IV DAPM GAMMA-SECRETASE INHIBITOR γ-Secretase Inhibitor XXI FLI-06
Semagacestat DAPT LY411575 RO4929097 MK-0752
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DIBENZAZEPINE N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide Dibenzazepine (Deshydroxy LY 411575) YO01027 γ-Secretase Inhibitor XX YO-01027/Dibenzazepine/LY 411575 (2S)-2-[2-(3,5-Difluorophenyl)acetaMide]-N-[(7S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[B,D]azepin-7- (S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7 YO-01027 (Dibenzazepine) (S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepi 7-(S)-[N'(3,5-difluorophenylacetyl)-L-alaninyl]amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide Deshydroxy LY-411575 GSI-XX γ-Secretase Inhibitor DBZ Dibenzazepine (deshydroxy LY 411575) DBZ Dibenzazepine (YO-01027) Dibenzazepine, 98%, γ-secretase inhibitor YO-01027; YO01027; DIBENZAZEPINE; DESHYDROXY LY 411575;DBZ CS-366 DBZ, γ-Secretase Inhibitor γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem YO-01027 (Dibenzazepine, DBZ) gamma-Secretase Inhibitor XX Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro- 6-Chloro-α-Tetralone γ-secretase,YO 01027,Gamma secretase,Notch,YO-01027,inhibit,YO01027,Inhibitor Dibenzazepine，LY-411575/Deshydroxy LY-411575 YO-01027, 10 mM in DMSO γ-Secretase Inhibitor XX 209984-56-5 C26H23F2N3O3 Inhibitor Inhibitors Intermediates & Fine Chemicals Pharmaceuticals A dipeptidic (c)-secretase inhibitor and anti-Alzheimer agent. All Inhibitors