1-Methyl-1-nitrosourea
- CAS No.
- 684-93-5
- Chemical Name:
- 1-Methyl-1-nitrosourea
- Synonyms
- N-NITROSO-N-METHYLUREA;MNU;NMU;NMH;Nitrosomethylurea;N-METHYL-N-NITROSOUREA;N-NITROSOMETHYLUREA;sri859;SRI 859;ski24464
- CBNumber:
- CB5109704
- Molecular Formula:
- C2H5N3O2
- Molecular Weight:
- 103.08
- MOL File:
- 684-93-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:09
| Melting point | 119-124°C |
|---|---|
| Boiling point | 193.27°C (rough estimate) |
| Density | 1.5048 (rough estimate) |
| refractive index | 1.4264 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: 125 mg/mL (1212.65 mM) |
| pka | 12.36±0.50(Predicted) |
| form | Solid |
| color | Off-white to light brown |
| Water Solubility | 14.56g/L(temperature not stated) |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, strong acids. |
| CAS DataBase Reference | 684-93-5(CAS DataBase Reference) |
| IARC | 2A (Vol. 17, Sup 7) 1987 |
| NIST Chemistry Reference | Urea, 1-methyl-1-nitroso-(684-93-5) |
| EPA Substance Registry System | N-Nitroso-N-methylurea (684-93-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H228-H301-H350-H360 |
| Precautionary statements | P201-P210-P301+P310-P308+P313 |
| Hazard Codes | F,T |
| Risk Statements | 45-46-61-11-25 |
| Safety Statements | 53-45-24/25-22 |
| RIDADR | UN 1325 4.1/PG 2 |
| WGK Germany | - |
| RTECS | YT7875000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29241990 |
| Toxicity | LD50 oral in rat: 110mg/kg |
1-Methyl-1-nitrosourea Chemical Properties,Uses,Production
Description
Methylnitrosourea (MNU) is a methylated nitrosourea compound with alkylating,mutagenic, teratogenic, carcinogenic, and cytotoxic properties. The toxic effects of MNU are caused by the transfer of its methyl group to nucleobases in nucleic acids.
Chemical Properties
Off-White to Pale Yellow Solid
Uses
Precursor of Diazomethane. It has a cytotoxicity effect. This product contains an undetermined amount of water
General Description
Pale yellow crystals or light yellow moist powder.
Air & Water Reactions
Sensitive to humidity and light when pure. Insoluble in water. Slowly decomposes in water. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas.
Reactivity Profile
1-Methyl-1-nitrosourea is incompatible with strong acids and bases. Also incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas. Can detonate with (potassium hydroxide + methylene chloride) .
Fire Hazard
Flash point data for 1-Methyl-1-nitrosourea are not available; however, 1-Methyl-1-nitrosourea is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion and intravenous routes. Experimental reproductive effects. Human mutation data reported. Explodes at room temperature. Can detonate with (KOH + CHzCh). When heated to decomposition it emits toxic fumes of NOx.
Carcinogenicity
N-Nitroso-N-methylurea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
There is no evidence that MNU has ever been produced or used commercially; therefore, no data from human case reports or epidemiological studies are available. MNU is available in small quantities for research purposes and may be released into the environment with laboratory waste. In air, MNU is expected to exist solely as a vapor with an estimated vapor pressure of 2.9×10-2 mmHg at 25℃. Vapor-phase MNU is expected to degrade in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 10 days. MNU is expected to hydrolyze in moist soils; therefore, MNU adsorption and volatilization from soil are not expected to be prevalent. In water,MNUis expected to hydrolyze and has a halflife of 1.2 h at pH 7 and 20℃; therefore, volatilization, adsorption into suspended solids and sediments, biodegradation, and bioconcentration are not expected to be important processes in aquatic systems. Occupational exposure to MNU may occur through oral contact, inhalation, and/or dermal contact at workplaces where it is used as a research chemical. Potential exposure may occur during the preparation and administration ofMNUor during clean up. To avoid spills,MNU should be transported in securely sealed glass bottles or ampules, which should themselves be placed inside strong screw-cap or snap-top containers that will not open when dropped. Both bottle and the outside container should be appropriately labeled.
1-Methyl-1-nitrosourea Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| NSR Laboratories Pvt. Ltd. | +91-9866989891 +91-9000457345 | Hyderabad, India | 196 | 58 | Inquiry |
| TANUJ PYRIDINE | 8790371027 | Hyderabad, India | 107 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| CHATURYA BIOTECH | +91-7702707258 +91-7702707258 | Telangana, India | 479 | 58 | Inquiry |
| AMINO ORGANICS | +919866989891 | Hyderabad, India | 275 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| REDDY N REDDY PHARMACEUTICALS | +91-9848096759 +91-9848096759 | Hyderabad, India | 1989 | 58 | Inquiry |
| TEADUS PHARMA PRIVATE LIMITED | +91-9740077663 +91-9740077663 | Telangana, India | 242 | 58 | Inquiry |
| TRUE LABS | +91-9948900000 +91-8919325074 | Telangana, India | 161 | 58 | Inquiry |
| SV CHEM INTERMEDITES PRIVATE LIMITED | +91-9940629423 +91-9940629423 | Tamil Nadu, India | 202 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| NSR Laboratories Pvt. Ltd. | 58 |
| TANUJ PYRIDINE | 58 |
| J S LABS | 58 |
| CHATURYA BIOTECH | 58 |
| AMINO ORGANICS | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| REDDY N REDDY PHARMACEUTICALS | 58 |
| TEADUS PHARMA PRIVATE LIMITED | 58 |
| TRUE LABS | 58 |
| SV CHEM INTERMEDITES PRIVATE LIMITED | 58 |