Chlorozotocin
- CAS No.
- 54749-90-5
- Chemical Name:
- Chlorozotocin
- Synonyms
- CZT;DCNU;CHLZ;CCRIS 879;NCS-178248;NCS-D-254157;Chlorozotocin;2-(3-(2-CHLOROETHYL)-3-NITROSOUREIDO)-D-GLUCOPYRANOSE;D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-
- CBNumber:
- CB71178262
- Molecular Formula:
- C9H16ClN3O7
- Molecular Weight:
- 313.69
- MOL File:
- 54749-90-5.mol
- Modify Date:
- 2023/5/4 17:34:39
| Melting point | 147-148° (dec with the evolution of gas); mp 140-141° (dec) |
|---|---|
| Boiling point | 119.3°C (rough estimate) |
| Density | 1.6475 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| pka | 9.08±0.46(Predicted) |
| IARC | 2A (Vol. 50) 1990 |
| EPA Substance Registry System | Chlorozotocin (54749-90-5) |
Chlorozotocin Chemical Properties,Uses,Production
Chemical Properties
Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001).
Uses
Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990).
Safety Profile
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NITROSAMINES.
Carcinogenicity
Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen.
Chlorozotocin Preparation Products And Raw materials
Raw materials
Preparation Products
Chlorozotocin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | China | 35426 | 58 | Inquiry | |
| TargetMol Chemicals Inc. | 4008200310 | China | 23980 | 58 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| Supplier | Advantage |
|---|---|
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| TargetMol Chemicals Inc. | 58 |
| PT CHEM GROUP LIMITED | 58 |
| TargetMol Chemicals Inc. | 58 |
| Lanospharma Laboratories Co.,Ltd | 56 |