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ergotamine

CAS No.: 113-15-5

Chemical Name:: ergotamine

Synonyms: ergotamin;NSC 95090;ergotamine;Ergotamine (8CI);ergotamine USP/EP/BP;XCGSFFUVFURLIX-VFGNJEKYSA-N;12'-Hydroxy-2'-methyl-5'α-benzylergotaman-3',6',18-trione;12’-hydroxy-2’-methyl-5’alpha-(phenylmethyl)ergotaman-3’,6’,18-trione;6’,18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-ergotaman-3(5’-alph;18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-6(5’alpha)-ergotaman-3

CBNumber:: CB2865180

Molecular Formula:: C33H35N5O5

Molecular Weight:: 581.66

MOL File:: 113-15-5.mol

Modify Date:: 2024/8/28 13:53:22

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ergotamine Properties

Melting point	241-249℃
alpha	D20 -160° (chloroform)
Boiling point	651.33°C (rough estimate)
Density	1.0998 (rough estimate)
refractive index	1.7500 (estimate)
pka	pKa 6.40±0.09(H2O t=24.0) (Uncertain)
optical activity	-16020 (CHCl3)
CAS DataBase Reference	113-15-5

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H330-H311-H361-H301
Precautionary statements	P280-P302+P352-P312-P322-P361-P363-P405-P501-P201-P202-P281-P308+P313-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501
RIDADR	1544
HazardClass	6.1(b)
PackingGroup	III
Toxicity	LD50 in mice, rats, rabbits (mg/kg): 62, 80, 3 i.v.; in cats: 11 s.c. (Rothlin)

ergotamine Chemical Properties,Uses,Production

Uses

Analgesic (specific in migraine).

Uses

Ergotamine, 3′,6′,18′-trione,12′-hydroxy-2′-methyl-5′-benzyl-(5α)-ergotamine (12.2.14), is obtained via microbiological synthesis [52].As an α-adrenoblocker, ergotamine exhibits a direct vasoconstricting effect for which it is used in medicine, particularly for alleviation of severe migraine attacks. It is categorically counterproductive in chronic diseases because of the possibility of side effects such as triggering gangrene.

Definition

ChEBI: A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.

Purification Methods

Crystallise it from *benzene, then dry it by prolonged heating in high vacuum. It is very hygroscopic. [Beilstein 25 III/IV 964.]

ergotamine Preparation Products And Raw materials

Raw materials

Preparation Products

DIHYDROERGOTAMINE

113-15-5(ergotamine)Related Search:

Ergotamine tartrate (7CI),Ergotamine, tartrate (2:1) (salt) (8CI),Medihaler-ergotamine,ERGOTAMINE D-TARTRATE, PH EUR,ERGOTAMINE TARTRATE DIHYDROERGOTAMINE DIHYDROERGOTAMINE MESYLATE ERGOCRISTINE ergotamine

ERGTOXIN DIHYDROERGOTAMINE TARTRATE Bromocriptine DIHYDROERGOTAMINE MESYLATE Ergotaminine

DIHYDROERGOTAMINE TARTRATE CRYSTALLINE ergostine Ergotamine tartrate·anhydrous caffeine ERGOTAMINE TARTRATE - * DRUG PRECURSOR L(-)-ERGOTAMINE-L(+)-TARTRATE

Dosergoside ERGOTAMINE TARTRATE GüG WHO(CRM STANDARD) ERGOTAMINE,SHEEPANTI-

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12’-hydroxy-2’-methyl-5’alpha-(phenylmethyl)ergotaman-3’,6’,18-trione 18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-6(5’alpha)-ergotaman-3 6’,18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-ergotaman-3(5’-alph ergotamine Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α)- Ergotamine (8CI) NSC 95090 12'-Hydroxy-2'-methyl-5'α-benzylergotaman-3',6',18-trione (5'alpha)-12'-Hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione XCGSFFUVFURLIX-VFGNJEKYSA-N Ergotaman-3',6',18-trione,12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'a)- ergotamine USP/EP/BP ergotamin (6aR,9R)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (ergotamine), 113-15-5 Organics