ERGOTAMINE TARTRATE
![ERGOTAMINE TARTRATE Structure](CAS/GIF/379-79-3.gif)
- CAS No.
- 379-79-3
- Chemical Name:
- ERGOTAMINE TARTRATE
- Synonyms
- ergomar;ergostat;etin;ergam;ergate;exmigra;lingran;secagyn;secupan;femergin
- CBNumber:
- CB9279489
- Molecular Formula:
- C70H76N10O16
- Molecular Weight:
- 1313.41
- MOL File:
- 379-79-3.mol
- Modify Date:
- 2024/3/14 15:18:30
Melting point | ~195 °C (dec.)(lit.) |
---|---|
alpha | D25 -125 to -155° (c = 0.4 in chloroform) |
storage temp. | 2-8°C |
Merck | 13,3696 |
BRN | 6173437 |
CAS DataBase Reference | 379-79-3(CAS DataBase Reference) |
EPA Substance Registry System | Ergotamine tartrate (379-79-3) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS06,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H301+H311+H331-H361 |
Precautionary statements | P261-P280-P301+P330+P331+P310-P302+P352+P312-P304+P340+P311-P403+P233 |
Hazard Codes | T |
Risk Statements | 23/24/25-62-63 |
Safety Statements | 36/37-45 |
RIDADR | UN 1544 6.1/PG 1 |
WGK Germany | 3 |
RTECS | KE8225000 |
F | 3-8-10 |
HazardClass | 6.1(b) |
PackingGroup | III |
HS Code | 29396200 |
ERGOTAMINE TARTRATE Chemical Properties,Uses,Production
Description
Ergotamine and ergometrine belong to two kinds of ergot alkaloids. Ergot (Claviceps
purpurea, 麦角) is the sclerotium of ergot fungus that grows in the rye and related
cereal and forage plants. The ergot is grown in the northeast and north China and
Xinjiang, Jiangsu, Zhejiang, Sichuan, and other places. At present, the method of
growth of ergot is inoculation cultivation.
Traditional Chinese medicine believes that ergot is tasteless, tepid, toxic, liver
meridian, and kidney meridian. The traditional usage of ergot is oral administration
of extractum, 2–4 ml each time, daily amount of 6–8 ml. Its dosage forms also contain
infusion, pills, injection, etc. Pharmacology of Chinese Medicine records ergot
can be used for uterine contraction, uterine bleeding, and postpartum hemorrhage
after delivery, incomplete recovery of uterus, retrogression, etc. The Plateau
Chinese herbal medicine treatment manual records that ergot can cure migraine.
Chemical Properties
Ergotamine tartrate is a crystalline solid.
Physical properties
Appearance: White or slightly yellow fine crystalline powder with slight hygroscopicity. Solubility: Slightly soluble in water and ethanol, insoluble in ether and chloroform.
Uses
Antimigraine.
Indications
Ergometrine maleate is used in the form of extract tumor injection. As a uterotonic,
ergometrine maleate is mainly used for the prevention and treatment of uterine
bleeding caused by weak or poor uterine contraction after delivery or abortion, as
well as the incomplete recovery of postpartum uterus to accelerate the recovery of
uterus.
Ergotamine tartrate is used for the treatment of migraine in the form of tablet and
parenteral solution. It also can be used for other neurogenic headache as well.
General Description
Powder or liquid forms available as drugs. Used in obstetrics and in the treatment of migraine headaches.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
ERGOTAMINE TARTRATE is sensitive to prolonged exposure to heat and light. . When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat [EPA, 1998].
Health Hazard
High oral toxicity and a convulsant in humans.People with liver damage are at a greater risk.
Fire Hazard
When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat
Clinical Use
Ergonovine maleate is mainly used for the prevention and treatment of the weak
uterine contraction or poor contraction caused by uterine bleeding after delivery or
abortion. It is also used for incomplete recovery of postpartum uterus to accelerate
the recovery of the uterus.
Ergotamine tartrate is mainly used for the treatment of migraine by relieving the
symptoms. However, it is only suitable for short-term usage of headache attacks,
normally does not prevent migraine. The combination of ergotamine tartrate and
caffeine is better than single oral administration with the mild side effects. It also
can be used for other neurogenic headaches.
Safety Profile
Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: hallucinations, dstorted perceptions, convulsions, nausea or vomiting, blood pressure elevation. Experimental reproductive effects. Human mutation data reported. Used in production of drugs of abuse. When heated to decomposition it emits toxic fumes of NOx. See also ERGOT.
Potential Exposure
(Toxicity evaluation); Suspected reprotoxic hazard, Suspected of causing genetic defects. The major uses of the ergot alkaloids fall into two categories: applications in obstetrics and treatment of migraine headaches. May be used in the production of “street” drugs
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required
Purification Methods
It crystallises from MeOH. [Beilstein 25 III/IV 964.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, light, and heat