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LDN 193189 hydrochloride

LDN 193189 hydrochloride Structure
CAS No.
1435934-00-1
Chemical Name:
LDN 193189 hydrochloride
Synonyms
DM-3189 2HCl;LDN-193189 2HC;LDN-193189 2HCl;LDN-193189 (DM3189) 2HCl;LDN 193189 dihydrochloride;LDN-193189 2HCl|||DM-3189 2HCl;Viomycin LDN 193189 Dihydrochloride;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
CBNumber:
CB03146321
Molecular Formula:
C25H24Cl2N6
Molecular Weight:
479.40426
MOL File:
1435934-00-1.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

LDN 193189 hydrochloride Properties

storage temp. -20°C
solubility Soluble in DMSO or in Water (up to 5 mg/ml)
form solid
color Orange-yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.

LDN 193189 hydrochloride Chemical Properties,Uses,Production

Description

LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

LDN 193189 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

LDN 193189 hydrochloride Suppliers

Global( 48)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
ShangHai ChuanQian Chemcial Technique Centre 15869524721 China 3617 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48467 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9155 58 Inquiry
Supplier Advantage
Career Henan Chemica Co 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
ShangHai ChuanQian Chemcial Technique Centre 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
RD International Technology Co., Limited 58

1435934-00-1(LDN 193189 hydrochloride)Related Search:

Z-FY-CHO 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Ibandronate sodium monohydrate 20ALPHA-HYDROXYCHOLESTEROL
LDN-193189 2HCl LDN 193189 dihydrochloride 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride Viomycin LDN 193189 Dihydrochloride DM-3189 2HCl LDN-193189 2HC LDN-193189 (DM3189) 2HCl LDN-193189 2HCl|||DM-3189 2HCl 1435934-00-1