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20ALPHA-HYDROXYCHOLESTEROL

CAS No.: 516-72-3

Chemical Name:: 20ALPHA-HYDROXYCHOLESTEROL

Synonyms: C05500;20-hydroxycholesterol;20A-HYDROXYCHOLESTEROL;20α-Hydroxy Cholesterol;Cholesterol Impurity 32;5-Cholestene-3B,20a-diol;5-cholestene-3β,20α-diol;Cholest-5-ene-3,20a-diol;Cholest-5-ene-3β,20-diol;20[S]-HYDROXYCHOLESTEROL

CBNumber:: CB2372501

Molecular Formula:: C27H46O2

Molecular Weight:: 402.65

MOL File:: 516-72-3.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:03

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20ALPHA-HYDROXYCHOLESTEROL Properties

Melting point	136-137°C
Boiling point	512.3±23.0 °C(Predicted)
Density	1.03±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in DMSO or in Ethanol.
form	Solid
pka	15.04±0.70(Predicted)
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

WGK Germany	3

20ALPHA-HYDROXYCHOLESTEROL price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	H6378	20α-Hydroxycholesterol analytical standard	516-72-3	5MG	₹17926.2	2022-06-14	Buy

Product number	Packaging	Price	Buy
H6378	5MG	₹17926.2	Buy

20ALPHA-HYDROXYCHOLESTEROL Chemical Properties,Uses,Production

Description

20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC₅₀ value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells. 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo. 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.

Chemical Properties

White Solid

Uses

A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effects

Definition

ChEBI: An oxysterol that is cholesterol substituted by a hydroxy group at position 20.

20ALPHA-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

4-METHYL-1-PENTYNE 1-Bromo-4-methylpentane 3-tert-Butyldimethylsilyloxy Pregnenolone Cholesterol Pregnenolone

Preparation Products

20ALPHA-HYDROXYCHOLESTEROL Suppliers

Global( 63)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	China	2016	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Shanghai Saikerui Biotechnology Co. , Ltd.	021-58000709 15900491054	China	9268	58	Inquiry
Henan Alfachem Co.,Ltd.	0371-0371-55051623 18137891487	China	9828	58	Inquiry
Cato Research Chemicals Inc.	020-81960175-877 18933936954	China	7721	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9155	58	Inquiry
Bide Pharmatech Ltd.	400-1647117 15221909166	China	63720	58	Inquiry
SHANGHAI ZZBIO CO., LTD.	19921389125 19921389125	China	12065	58	Inquiry
Shanghai Jieshikai Biotechnology Co. , Ltd.	021-57520305 15221441005	China	49242	58	Inquiry

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Shanghai Saikerui Biotechnology Co. , Ltd.	58
Henan Alfachem Co.,Ltd.	58
Cato Research Chemicals Inc.	58
RD International Technology Co., Limited	58
Bide Pharmatech Ltd.	58
SHANGHAI ZZBIO CO., LTD.	58
Shanghai Jieshikai Biotechnology Co. , Ltd.	58

20ALPHA-HYDROXYCHOLESTEROL Spectrum

20ALPHA-HYDROXYCHOLESTEROL(516-72-3)¹HNMR

516-72-3(20ALPHA-HYDROXYCHOLESTEROL)Related Search:

2,3-DIMETHYL-2-HEXANOL octadecene 4-CYCLOHEXYLCYCLOHEXANOL 5-ETHYL-3-NONANOL 3-DECANOL

5-METHYL-5-NONANOL 2-BUTYL-1-OCTANOL (S)-(+)-4-METHYL-2-PENTANOL 6-TRIDECANOL CIS-4-NONENE

20ALPHA-HYDROXYCHOLESTEROL 4-METHYL-5-OCTANOL 3-DODECANOL TRANS-9-DODECEN-1-OL (S)-(+)-2-NONANOL

4-METHYL-4-PENTEN-2-OL 3-METHYL-4-OCTANOL dodec-11-enol

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20alpha-Hydroxycholesterol (not deuterated) 5-Cholestene-3B,20a-diol Cholest-5-ene-3,20-diol, (3.beta.)- 5-cholestene-3β,20α-diol (3S,8S,9S,10R,13S,14S,17S)-17-[(2R)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 20α-Hydroxycholesterol (not deuterated) (20S)-Cholest-5-ene-3,20-diol (3)-Cholest-5-ene-3,20-diol 20S-Cholest-5-ene-3,20-diol Cholest-5-ene-3,20a-diol (20S)-20-Hydroxycholesterol Cholest-5-ene-3β,20-diol C05500 20A-HYDROXYCHOLESTEROL 20ALPHA-HYDROXYCHOLESTEROL 20[S]-HYDROXYCHOLESTEROL 3BETA,20ALPHA-DIHYDROXY-5-CHOLESTENE 5-CHOLESTENE-3B,20ALPHA-DIOL 5-CHOLESTENE-3BETA,20ALPHA-DIOL 5-CHOLESTEN-3-BETA, 20-ALPHA-DIOL 20-hydroxycholesterol (3S,8S,9S,10R,13S,14S,17S)-17-((S)-2-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) Cholest-5-ene-3,20-diol, (3β)- 20α-Hydroxy Cholesterol Cholesterol Impurity 32 (8S,9S,10R,13S,14S,17S)-17-((R)-2-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 5-CHOLESTEN-3β, 20α-DIOL 516-72-3 HU - HZ Alphabetic Analytical Standards Analytical Chromatography Product Catalog Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids Standards - 13C & 2H for GC-Mass Spectrometry