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20ALPHA-HYDROXYCHOLESTEROL

CAS No.: 516-72-3

Chemical Name:: 20ALPHA-HYDROXYCHOLESTEROL

Synonyms: C05500;20-hydroxycholesterol;20A-HYDROXYCHOLESTEROL;20α-Hydroxy Cholesterol;Cholesterol Impurity 32;5-Cholestene-3B,20a-diol;5-cholestene-3β,20α-diol;Cholest-5-ene-3,20a-diol;Cholest-5-ene-3β,20-diol;20[S]-HYDROXYCHOLESTEROL

CBNumber:: CB2372501

Molecular Formula:: C27H46O2

Molecular Weight:: 402.65

MOL File:: 516-72-3.mol

MSDS File:: SDS

Modify Date:: 2025/1/27 9:38:02

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20ALPHA-HYDROXYCHOLESTEROL Properties

Melting point	136-137°C
Boiling point	512.3±23.0 °C(Predicted)
Density	1.03±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in DMSO or in Ethanol.
form	Solid
pka	15.04±0.70(Predicted)
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

WGK Germany	3

20ALPHA-HYDROXYCHOLESTEROL price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	H6378	20α-Hydroxycholesterol analytical standard	516-72-3	5MG	₹17926.2	2022-06-14	Buy

Product number	Packaging	Price	Buy
H6378	5MG	₹17926.2	Buy

20ALPHA-HYDROXYCHOLESTEROL Chemical Properties,Uses,Production

Description

20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC₅₀ value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells. 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo. 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.

Chemical Properties

White Solid

Uses

A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effects

Definition

ChEBI: An oxysterol that is cholesterol substituted by a hydroxy group at position 20.

20ALPHA-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

4-METHYL-1-PENTYNE 1-Bromo-4-methylpentane 3-tert-Butyldimethylsilyloxy Pregnenolone Cholesterol Pregnenolone

Preparation Products

20ALPHA-HYDROXYCHOLESTEROL Suppliers

Global( 81)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	China	3978	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
TargetMol Chemicals Inc.		United States	38630	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	China	33338	58	Inquiry
TargetMol Chemicals Inc.	+8613564774135	United States	19881	58	Inquiry
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	China	40066	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24642	58	Inquiry
Cato Research Chemicals Inc.	18933936954	China	17709	58	Inquiry
Shanghai Saikerui Biotechnology Co. , Ltd.	021-58000709 15900491054	China	9522	58	Inquiry
Henan Alfachem Co.,Ltd.	0371-0371-0371-55051623 18137891487	China	10010	58	Inquiry

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
TargetMol Chemicals Inc.	58
Cato Research Chemicals Inc.	58
Shanghai Saikerui Biotechnology Co. , Ltd.	58
Henan Alfachem Co.,Ltd.	58

20ALPHA-HYDROXYCHOLESTEROL Spectrum

20ALPHA-HYDROXYCHOLESTEROL(516-72-3)¹HNMR

516-72-3(20ALPHA-HYDROXYCHOLESTEROL)Related Search:

2,3-DIMETHYL-2-HEXANOL octadecene 4-CYCLOHEXYLCYCLOHEXANOL 5-ETHYL-3-NONANOL 3-DECANOL

5-METHYL-5-NONANOL 2-BUTYL-1-OCTANOL (S)-(+)-4-METHYL-2-PENTANOL 6-TRIDECANOL CIS-4-NONENE

20ALPHA-HYDROXYCHOLESTEROL 4-METHYL-5-OCTANOL 3-DODECANOL TRANS-9-DODECEN-1-OL (S)-(+)-2-NONANOL

4-METHYL-4-PENTEN-2-OL 3-METHYL-4-OCTANOL dodec-11-enol

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20alpha-Hydroxycholesterol (not deuterated) 5-Cholestene-3B,20a-diol Cholest-5-ene-3,20-diol, (3.beta.)- 5-cholestene-3β,20α-diol (3S,8S,9S,10R,13S,14S,17S)-17-[(2R)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 20α-Hydroxycholesterol (not deuterated) (20S)-Cholest-5-ene-3,20-diol (3)-Cholest-5-ene-3,20-diol 20S-Cholest-5-ene-3,20-diol Cholest-5-ene-3,20a-diol (20S)-20-Hydroxycholesterol Cholest-5-ene-3β,20-diol C05500 20A-HYDROXYCHOLESTEROL 20ALPHA-HYDROXYCHOLESTEROL 20[S]-HYDROXYCHOLESTEROL 3BETA,20ALPHA-DIHYDROXY-5-CHOLESTENE 5-CHOLESTENE-3B,20ALPHA-DIOL 5-CHOLESTENE-3BETA,20ALPHA-DIOL 5-CHOLESTEN-3-BETA, 20-ALPHA-DIOL 20-hydroxycholesterol (3S,8S,9S,10R,13S,14S,17S)-17-((S)-2-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) Cholest-5-ene-3,20-diol, (3β)- 20α-Hydroxy Cholesterol Cholesterol Impurity 32 (8S,9S,10R,13S,14S,17S)-17-((R)-2-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 5-CHOLESTEN-3β, 20α-DIOL 20(S)-Hydroxycholesterol, Smoothened activator 20(S)-Hydroxycholesterol, 10 mM in DMSO 516-72-3 HU - HZ Alphabetic Analytical Standards Analytical Chromatography Product Catalog Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids Standards - 13C & 2H for GC-Mass Spectrometry