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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Forensic and veterinary standards >20ALPHA-HYDROXYCHOLESTEROL

20ALPHA-HYDROXYCHOLESTEROL

20ALPHA-HYDROXYCHOLESTEROL Structure
  • ₹17926.2
  • Product name: 20ALPHA-HYDROXYCHOLESTEROL
  • CAS: 516-72-3
  • MF: C27H46O2
  • MW: 402.65
  • EINECS:
  • MDL Number:MFCD16661190
  • Synonyms:20alpha-Hydroxycholesterol (not deuterated);5-Cholestene-3B,20a-diol;Cholest-5-ene-3,20-diol, (3.beta.)-;5-cholestene-3β,20α-diol;(3S,8S,9S,10R,13S,14S,17S)-17-[(2R)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;20α-Hydroxycholesterol (not deuterated);(20S)-Cholest-5-ene-3,20-diol;(3)-Cholest-5-ene-3,20-diol
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberH6378
  • Product description20α-Hydroxycholesterol analytical standard
  • Packaging5MG
  • Price₹17926.2
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) H6378 20α-Hydroxycholesterol analytical standard 5MG ₹17926.2 2022-06-14 Buy

Properties

Melting point :136-137°C
Boiling point :512.3±23.0 °C(Predicted)
Density :1.03±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :Soluble in DMSO or in Ethanol.
form :Solid
pka :15.04±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

20α-Hydroxy Cholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein that binds at a site distinct from the canonical cyclopamine binding site. 20α-Hydroxy Cholesterol activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). It induces Smo accumulation in primary cilia and also exhibits osteogenic activity and activates the liver X receptor (LXR).

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