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Pimodivir

Pimodivir Structure
CAS No.
1629869-44-8
Chemical Name:
Pimodivir
Synonyms
VX-787;CS-2483;Pimodivir;VRT0928787;VRT 0928787;VRT-0928787;JNJ63623872;JNJ 63623872;JNJ-63623872;Pimodivir (VX-787)
CBNumber:
CB03169595
Molecular Formula:
C20H19F2N5O2
Molecular Weight:
399.39
MOL File:
1629869-44-8.mol
Modify Date:
2024/7/2 8:54:58
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Pimodivir Properties

Density 1.501±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO, not in water:100.0(Max Conc. mg/mL);250.38(Max Conc. mM)
form A solid
pka 4.32±0.40(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

Pimodivir Chemical Properties,Uses,Production

Description

Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; KD = <0.003 μM). It also binds to glycogen synthase kinase 3β (GSK3β; Ki = ~1.6 μM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = <0.15-2.8 nM in a cell-based assay). It increases the antiviral activity of oseltamivir , zanamivir , and favipiravir (T-705; ) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay. Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.

Uses

Pimodivir is an orally bioavailable azaindole inhibitor of influenza PB2.

Pimodivir Preparation Products And Raw materials

Raw materials

Preparation Products

Pimodivir Suppliers

Global( 66)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 China 25363 58 Inquiry
Jiangxi Huihe Chemical Co., Ltd. +86-19189228086 +8618858568638 China 886 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
Career Henan Chemica Co 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Jiangxi Huihe Chemical Co., Ltd. 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
LEAPCHEM CO., LTD. 58

1629869-44-8(Pimodivir)Related Search:

VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide AVN-944 VE 822 Telaprevir
VX-770
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Pimodivir Pimodivir (VX-787) VX-787 VRT0928787 VRT-0928787 VX-787; VX 787; VX787; JNJ-872; JNJ 872; JNJ872; VRT-0928787; VRT 0928787; VRT0928787;PIMODIVIR VX-787 (Pimodivir) Bicyclo[2.2.2]octane-2-carboxylic acid, 3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-, (2S,3S)- (2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]bicyclo[2.2.2]octane-2-carboxylic acid CS-2483 VRT 0928787 Influenza Virus,Inhibitor,inhibit,VX787,Pimodivir,VX 787 JNJ 63623872 JNJ63623872 JNJ-63623872 1629869-44-8