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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >p38 MAPK inhibitor >VX-745

VX-745

VX-745 Structure
CAS No.
209410-46-8
Chemical Name:
VX-745
Synonyms
CS-1918;VD31745;VX-745, >=96%;VX-745(VX 745);VX-745 (Free base);NEFLAMAPIMOD;VX 745;Naluzotan Hydrochloride;Neflamapimod (VX745, VRT031745;Neflamapimod VX-745 MAPK inhibitor;Inhibitor,VX745,Neflamapimod,Autophagy,VX 745,inhibit,p38 MAPK
CBNumber:
CB8511364
Molecular Formula:
C19H9Cl2F2N3OS
Molecular Weight:
436.26
MOL File:
209410-46-8.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

VX-745 Properties

Melting point 261-264 °C
Boiling point 578.9±60.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility ≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form powder
pka -0.97±0.40(Predicted)
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933599590

VX-745 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1638 VX-745 ≥98% (HPLC) 209410-46-8 5MG ₹11233.2 2022-06-14 Buy
Sigma-Aldrich(India) SML1638 VX-745 ≥98% (HPLC) 209410-46-8 25MG ₹45177 2022-06-14 Buy
Product number Packaging Price Buy
SML1638 5MG ₹11233.2 Buy
SML1638 25MG ₹45177 Buy

VX-745 Chemical Properties,Uses,Production

Description

VX-745 is an inhibitor of p38α MAPK (IC50 = 9 nM). It is selective for p38α over p38β MAPK (Ki = 220 nM) as well as ERK, JNK, and a panel of 50 kinases when used at a concentration of 2 μM. VX-745 inhibits LPS-induced production of IL-1β and TNF-α in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 45 and 51 nM, respectively). It reduces disease severity in a type II collagen-induced mouse model of arthritis when administered at a dose of 10 mg/kg.

Chemical Properties

Pale Yellow Solid

Definition

ChEBI: A member of the class of pyrimidopyridazines that is 6H-pyrimido[1,6-b]pyridazin-6-one substituted at positions 2 and 5 by (2,4-difluorophenyl)sulfanyl and 2,6-dichlorophenyl groups respectively

VX-745 Preparation Products And Raw materials

Raw materials

Preparation Products

VX-745 Suppliers

Global( 143)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Xi'an Yutbon Pharmaceutical Technology Co., Ltd 029-81140587 +8618717328141 China 453 58 Inquiry
Unipharm pharmaceutical industry Co., Ltd 536-8266195 +8613953676784 China 1206 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd 58
Unipharm pharmaceutical industry Co., Ltd 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

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6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]- (9CI) 6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]- 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6H-pyriMido[3,4-b]pyridazin-6-one VX-745(VX 745) 5-(2,6-Dichloro-phenyl)-2-(2,4-difluoro-phenylsulfanyl)-1,7,8a-triaza-naphthalen-6-one 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one VX-745 VX-745 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one VX-745, >=96% VX-745 (Free base) Naluzotan Hydrochloride 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-on 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one CS-1918 NEFLAMAPIMOD;VX 745 Neflamapimod (VX745, VRT031745 VD31745 Neflamapimod VX-745 MAPK inhibitor Inhibitor,VX745,Neflamapimod,Autophagy,VX 745,inhibit,p38 MAPK 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one 209410-46-8 C19H9Cl2F2N3OS MAPK Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds