Lumacaftor (VX-809)
- CAS No.
- 936727-05-8
- Chemical Name:
- Lumacaftor (VX-809)
- Synonyms
- Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;Rumakato;VRT 826809;3-(6-{[1-(2;VX809;VX-809
- CBNumber:
- CB32489655
- Molecular Formula:
- C24H18F2N2O5
- Molecular Weight:
- 452.41
- MOL File:
- 936727-05-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/2/21 21:32:25
| Melting point | 200-205oC |
|---|---|
| Boiling point | 653.0±55.0 °C(Predicted) |
| Density | 1.51 |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.95±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChIKey | UFSKUSARDNFIRC-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C5OC(F)(F)OC5=C4)CC3)=O)=CC=C2C)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Lumacaftor (VX-809) Chemical Properties,Uses,Production
Uses
VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.
Mode of action
CF is a hereditary condition caused by mutations in the CFTR gene, which provides instructions for producing an ion channel protein called CF transmembrane conductance regulator (CFTR). These mutations cause defects in the CFTR protein, which disrupts the normal salt-water transport across the cell membrane and produces thick, sticky mucus that may accumulate in different organs, including the lungs. One of the common mutations in the CFTR gene is the so-called F508del mutation, which results in a defective misfolded CFTR protein. The misfolded protein is degraded by the cell before it can reach the cell membrane. Even if some of the defective proteins reach the cell membrane, they are unable to open correctly and allow the passage of chloride ions. Lumacaftor and ivacaftor work together to restore the function of the CFTR protein at the cell membrane. Lumacaftor increases the stability of defective CFTR proteins, helping them reach the cell membrane and stay there longer. But because it does not address the problem with the opening of the channel, lumacaftor is generally used in combination with ivacaftor, which acts on the defective proteins, helping them to open more often so that the salt-water balance across the cell surface is restored.
Lumacaftor (VX-809) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Maithri Drugs Pvt Ltd | +91-9059204566 +91-9848881740 | Telangana, India | 64 | 58 | Inquiry |
| MAITHRI DRUGS PRIVATE LTD | +91 40 30438600 | New Delhi, India | 29 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd. | +86-0311-67591193 +8613931880626 | China | 256 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 | China | 8809 | 58 | Inquiry |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | China | 12817 | 58 | Inquiry |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | China | 2998 | 58 | Inquiry |
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