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VX-661

VX-661 Structure
CAS No.
1152311-62-0
Chemical Name:
VX-661
Synonyms
tezacaftor(VX661);(R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-Methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxaMide;CS-956;VX-661;VX-661/VX661;VX661/Tezacaftor;VX-661 USP/EP/BP;VX 661; VX661;VX-661;VX 661;VX661;VX-661; TEZACAFTOR;Tezacaftor D4Q: What is Tezacaftor D4 Q: What is the CAS Number of Tezacaftor D4
CBNumber:
CB22632076
Molecular Formula:
C26H27F3N2O6
Molecular Weight:
520.5
MOL File:
1152311-62-0.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:03
Request For Quotation

VX-661 Properties

Boiling point 610.8±55.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. Store at -20°C , stored under nitrogen
solubility ≥21.8 mg/mL in DMSO; insoluble in EtOH; ≥24.3 mg/mL in H2O
form solid
pka 13.99±0.20(Predicted)
color White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

VX-661 Chemical Properties,Uses,Production

Description

Tezacaftor (VX-661) is an oral medication for cystic fibrosis (CF) developed by Vertex Pharmaceuticals. In a combination therapy formulation called Symdeko (tezacaftor plus ivacaftor), it is approved in the U.S. and Canada for CF patients, ages 12 and older, who have two copies of the F508del mutation in the CFTR gene and one minimal function mutation. Symdeko is approved and marketed in the EU as Symkevi.Tezacaftor is not approved as a stand-alone treatment, but as part of a combination therapy.

Uses

Tezacaftor is used as a combination therapy with Ivacaftor for the treatment of patients with cystic fibrosis.

Definition

VX-661 is an investigational compound that promotes the maturation of delta F508 mutants of the cystic fibrosis transmembrane conductance regulator (CFTR). Delta F508 CFTR represents a class of CFTR mutation that is characterized by impaired processing of misfolded CFTR proteins and reduced accumulation of the protein at the cell surface. VX-661 is intended to facilitate trafficking of CFTR to the epithelial cell membrane. It may be combined with the CFTR potentiator ivacaftor (Item No. 15145) to stimulate both CFTR accumulation and opening at the apical epithelial surface.

VX-661 Preparation Products And Raw materials

Raw materials

Preparation Products

VX-661 Suppliers

Global( 165)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
ENBRIDGE PHARMTECH CO., LTD. +8613812269233 China 303 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
SynZeal Research Pvt Ltd 58
Hangzhou FandaChem Co.,Ltd. 55
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
ENBRIDGE PHARMTECH CO., LTD. 58

VX-661 Spectrum

VX-661(1152311-62-0)1HNMR

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VX-661 VX-661/VX661 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]- 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide VX661 (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy- CS-956 VX661/Tezacaftor VX 661; VX661;VX-661 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide VX 661;VX661;VX-661; TEZACAFTOR Tezacaftor D4Q: What is Tezacaftor D4 Q: What is the CAS Number of Tezacaftor D4 VX-661 USP/EP/BP (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-Methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxaMide tezacaftor(VX661) inhibit,Tezacaftor,Inhibitor,VX-661,Cystic fibrosis transmembrane conductance regulator,Autophagy,VX 661,CFTR N,3,3-Trimethyl-1,5-dioxaspiro[5.5]undecan-9-amine Hydrochloride (4-Methylaminocyclohexanone 2',2'-Dimethyltrimethylene Ketal Hydrochloride) (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-[1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methyl-2-propyl)-5-indolyl]cyclopropanecarboxamide 1152311-62-0 C26H27F3N2O6 Inhibitors API