CFTRinh-172
- CAS No.
- 307510-92-5
- Chemical Name:
- CFTRinh-172
- Synonyms
- CS-1067;CFTR(INH)-172;CFTR INHIBITOR-172;CFTRinh-172 USP/EP/BP;InSolution? CFTR Inhibitor-172;CFTR INHIBITOR-172;CFTRINH-172;CFTRinh 172 (CFTR Inhibitor-172);CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem;4-[[4-Oxo-2-Thioxo-3-[3-(Trifluoromethyl)Phenyl]Thiazolidin-;InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
- CBNumber:
- CB0364629
- Molecular Formula:
- C18H10F3NO3S2
- Molecular Weight:
- 409.4
- MOL File:
- 307510-92-5.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 181-183 °C |
|---|---|
| Boiling point | 555.7±60.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | Yellow solid |
| pka | 3.88±0.10(Predicted) |
| color | yellow |
| CAS DataBase Reference | 307510-92-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335-H410 | |||||||||
| Precautionary statements | P261-P273-P280-P305+P351+P338-P501 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-43-50/53 | |||||||||
| Safety Statements | 26-36/37-60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
CFTRinh-172 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C2992 | CFTR(inh)-172 ≥98% (HPLC), powder | 307510-92-5 | 5MG | ₹16562.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C2992 | CFTR(inh)-172 ≥98% (HPLC), powder | 307510-92-5 | 25MG | ₹66974.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 219674 | InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem The InSolution CFTR Inhibitor-172, also referenced under CAS 307510-92-5, controls the biological activity of CFTR. This small molecule/inhibitor is p | 307510-92-5 | 5MG | ₹16390 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 219670 | CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem CFTR Inhibitor-172, CAS 307510-92-5, is a cell-permeable, potent, reversible, rapid, and voltage-independent inhibitor of CFTR-mediated Cl- transport | 307510-92-5 | 5MG | ₹20320 | 2022-06-14 | Buy |
CFTRinh-172 Chemical Properties,Uses,Production
Uses
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR Inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner. It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels. In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection. It slows cyst growth in animal models of polycystic kidney disease. As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.
Definition
ChEBI: A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane con uctance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.
Biological Activity
Voltage-independent, selective CFTR chloride channel blocker (K i = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.
CFTRinh-172 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | China | 694 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |