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Difluoro Atorvastatin Acetonide tert-Butyl Ester

Difluoro Atorvastatin Acetonide tert-Butyl Ester Structure
CAS No.
693793-87-2
Chemical Name:
Difluoro Atorvastatin Acetonide tert-Butyl Ester
Synonyms
Atorvastatin calcium-20;Atorvastatin Impurity Ⅳ;Atorvastatin Impurity 41;Atorvastatin calcium impurity 28;Difluoro Atorvastatin Acetonide tert-Butyl Ester;tert-Butyl (4R,6R)-6-[2-[2,3-Bis(4-fluorophenyl)-5-isopropyl-4-(phenylcarbamoyl)-1-pyrrolyl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate;tert-butyl 2-((4R,6R)-6-(2-(2,3-bis(4-fluorophenyl)-5-isopropyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate;1,3-Dioxane-4-acetic acid, 6-[2-[2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-;Atorvastatin impurity 19/Difluoro Atorvastatin Acetonide tert-Butyl Ester/(4R,6R)-6-[2-[2,3-Bis(4-fluorophenyl)-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-Dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
CBNumber:
CB03355901
Molecular Formula:
C40H46F2N2O5
Molecular Weight:
672.8
MOL File:
693793-87-2.mol
Modify Date:
2023/4/23 13:52:06

Difluoro Atorvastatin Acetonide tert-Butyl Ester Properties

Melting point 173 - 175°C
Boiling point 677.4±55.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly), Methanol (Slightly)
pka 13.38±0.70(Predicted)
form Solid
color Off-White to Pale Yellow

Difluoro Atorvastatin Acetonide tert-Butyl Ester Chemical Properties,Uses,Production

Uses

Difluoro Atorvastatin Acetonide tert-Butyl Ester is a useful synthetic intermediate in the synthesis of Difluoro Atorvastatin (D445660); an Atorvastatin impurity.

Difluoro Atorvastatin Acetonide tert-Butyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

1,3-Dioxane-4-acetic acid, 6-[2-[2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- Atorvastatin impurity 19/Difluoro Atorvastatin Acetonide tert-Butyl Ester/(4R,6R)-6-[2-[2,3-Bis(4-fluorophenyl)-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-Dioxane-4-acetic Acid 1,1-Dimethylethyl Ester Atorvastatin calcium-20 Atorvastatin Impurity 41 Atorvastatin Impurity Ⅳ tert-butyl 2-((4R,6R)-6-(2-(2,3-bis(4-fluorophenyl)-5-isopropyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate Atorvastatin calcium impurity 28 tert-Butyl (4R,6R)-6-[2-[2,3-Bis(4-fluorophenyl)-5-isopropyl-4-(phenylcarbamoyl)-1-pyrrolyl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate Difluoro Atorvastatin Acetonide tert-Butyl Ester 693793-87-2 C40H46F2N2O5