Atorvastatin tert-Butyl Ester

Atorvastatin tert-Butyl Ester Structure
CAS No.
134395-00-9
Chemical Name:
Atorvastatin tert-Butyl Ester
Synonyms
Atorvastatin t-butyl ester;(3R,5R);Atorvastatin 1;Atorvastatin calcium-8;Atorvastatin Impurity 21;Atorvastatin EP Impurity N;ATV imp N ( tertbutyl ester);Atorvastatin tert-Butyl Ester;Trimethyl thiazole 13623-11-5;Atorvastatin Calcium Impurity N
CBNumber:
CB21176137
Molecular Formula:
C37H43FN2O5
Molecular Weight:
614.75
MOL File:
134395-00-9.mol
Modify Date:
2023/5/4 15:16:19

Atorvastatin tert-Butyl Ester Properties

Melting point 66-68°C
Boiling point 721.0±60.0 °C(Predicted)
Density 1.16
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
pka 13.57±0.70(Predicted)
color White to Off-White
PH 6.22 at 25℃ and 10mg/L
CAS DataBase Reference 134395-00-9

SAFETY

Risk and Safety Statements

Hazard statements  H413

Atorvastatin tert-Butyl Ester Chemical Properties,Uses,Production

Chemical Properties

Off-white to pale yellow solid

Uses

An impurity arising in the synthesis of Atorvastatin

Atorvastatin tert-Butyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(4R-cis)-1,1-diMethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrro-1-yl]ethyl]-2,2-diMethyl-1,3-dihydroxy-4-acetate (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-DiMethylethyl Ester (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid tert-butyl ester (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl) (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-, 1,1-diMethylethyl ester, (βR,δR)- Atorvastatin 1 (3R,5R) -tert-Butyl 7-(2-(4-fluorophenyl) (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1- 7-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5- dihydroxy-heptanoic Acid tert-Butyl Ester Atorvastatin tert-Butyl Ester (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester Atorvastatin Impurity O reference substance tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate Atorvastatin Impurity 3(Atorvastatin EP Impurity N) tert-butyl(3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate Atorvastatin 3-Fluoro t-Butyl Ester Atorvastatin impurity 11/Atorvastatin tert-Butyl Ester/(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate Atorvastatin calcium-8 (3R,5R)-tert-butyl 7-(2-(4-fluorophenyl) Atorvastatin tert-Butyl Ester (Atorvastatin Impurity 3) Atorvastatin EP Impurity N Atorvastatin Calcium Hydrate impurity O Atorvastatin Impurity 21 (βR,δR)-Atorvastatin tert-Butyl Ester (> (βR,δR)-Atorvastatin tert-Butyl Ester (βR,δR)-Atorvastatin tert-Butyl Ester (>90%) Atorvastatin Acid tert-Butyl Ester Atorvastatin Acid t-Butyl EsterQ: What is Atorvastatin Acid t-Butyl Ester Q: What is the CAS Number of Atorvastatin Acid t-Butyl Ester Q: What is the storage condition of Atorvastatin Acid t-Butyl Ester Q: What are the applications of Atorvastatin Acid t-Butyl Ester ATV imp N ( tertbutyl ester) Atorvastatin t-butyl ester Trimethyl thiazole 13623-11-5 Atorvastatin Calcium Impurity N Atorvastatin Calcium EP Impurity N Atorvastatin calcium impurity 15 Atorvastatin Impurity 3 (Atorvastatin tert-Butyl Ester) Atorvastatin EP Impurity-N (t-Butyl ester) Atorvastatin EP Impurity N (Atorvastatin tert-Butyl Ester) (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester Atorvastatin Acid t-Butyl Ester (3R,5R)-7-[3-(Phenylcarbamoyl)-5-(4-fluorophenyl)-2isopropyl-4- phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate (Atorvastatin calcium Impurity) 134395-00-9 C37H43FN2O5 Atorvastatin intermediates Pfizer compounds Chiral Reagents Inhibitors Intermediates & Fine Chemicals Pharmaceuticals