5-HYDROXYINDOLE-3-ACETIC ACID
- CAS No.
- 54-16-0
- Chemical Name:
- 5-HYDROXYINDOLE-3-ACETIC ACID
- Synonyms
- 5-HIAA;HIAA;2-(5-hydroxy-1H-indol-3-yl)acetic acid;5-oxyindoleaceticacid;5-HYDROXY-3-INDOLEACETIC ACID;5&＃039;5-HO-IAA;NSC 90432;Nature Product;TIMTEC-BB SBB003639
- CBNumber:
- CB0362913
- Molecular Formula:
- C10H9NO3
- Molecular Weight:
- 191.18
- MOL File:
- 54-16-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:03
| Melting point | 161-164 °C (dec.) (lit.) |
|---|---|
| Boiling point | 326.92°C (rough estimate) |
| Density | 1.2722 (rough estimate) |
| refractive index | 1.5310 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in ethanol (50 mg/ml). |
| pka | 4.54±0.30(Predicted) |
| form | crystalline |
| color | off-white to purple |
| Sensitive | Light Sensitive |
| BRN | 168797 |
| Stability | Air Sensitive, Light Sensitive |
| InChIKey | DUUGKQCEGZLZNO-UHFFFAOYSA-N |
| CAS DataBase Reference | 54-16-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL3650000 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29339980 | |||||||||
| NFPA 704 |
|
5-HYDROXYINDOLE-3-ACETIC ACID price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H8876 | 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | 54-16-0 | 100MG | ₹3420.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H8876 | 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | 54-16-0 | 500MG | ₹10489.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H8876 | 5-Hydroxyindole-3-acetic acid ≥98% (HPLC), crystalline | 54-16-0 | 1G | ₹17428.25 | 2022-06-14 | Buy |
| ALFA India | ALF-J61435-ME | 5-Hydroxyindole-3-acetic acid, 98% | 54-16-0 | 500mg | ₹2708 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0355 | 5-Hydroxyindole-3-acetic Acid | 54-16-0 | 100MG | ₹3100 | 2022-05-26 | Buy |
5-HYDROXYINDOLE-3-ACETIC ACID Chemical Properties,Uses,Production
Description
5-hydroxy Indole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT; ). It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for detection of neuroendocrine tumors and an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. 5-HIAA has also been associated with autism, insomnia, and chronic migraine.
Chemical Properties
beige crystalline powder
Uses
5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.
Definition
ChEBI: A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
General Description
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Mechanism of action
The primary product of the metabolism of serotonin. Formed by the oxidative deamination of serotonin by monoamine oxidase, presumably the A isozyme, 5-HIAA is subsequently cleared by an active transport mechanism. Unlike serotonin, 5-HIAA is not a neurotransmitter and thus its formation contributes to the termination of the synaptic actions of serotonin. Inhibition of monoamine oxidase activity enhances and prolongs the actions of serotonin.
5-HYDROXYINDOLE-3-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Souvenier Chemicals | 08048372762Ext 645 | Mumbai, India | 396 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
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