DRB
- CAS No.
- 53-85-0
- Chemical Name:
- DRB
- Synonyms
- DRB;DBR;NSC 401575;DRB USP/EP/BP;DRB (Benzimidazole);dichlororibofuranosylbenzimidazole;5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE;Dichlorobenzimidazoleribofuranoside;5,6-dichloro-1-β-D-ribobenzimidazole;5,6-dichlorobenzimidazoleriboside(drb)
- CBNumber:
- CB0367110
- Molecular Formula:
- C12H12Cl2N2O4
- Molecular Weight:
- 319.14
- MOL File:
- 53-85-0.mol
- Modify Date:
- 2023/5/18 11:31:04
| Melting point | 222-224°C |
|---|---|
| Boiling point | 606.2±65.0 °C(Predicted) |
| Density | 1.5917 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 20 mg/ml) |
| pka | 13.23±0.70(Predicted) |
| form | White solid |
| color | White |
| Water Solubility | Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers. |
| λmax | 296nm(lit.) |
| BRN | 39123 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | XHSQDZXAVJRBMX-AYLPWXGPSA-N |
| CAS DataBase Reference | 53-85-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | DD7310000 |
| HS Code | 29349990 |
DRB price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D1916 | 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside | 53-85-0 | 10MG | ₹7166.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D1916 | 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside | 53-85-0 | 50MG | ₹21000.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 287891 | 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC?? = 6 μM). | 53-85-0 | 50MG | ₹17860 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4292 | 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside | 53-85-0 | 100MG | ₹5700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4292 | 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside | 53-85-0 | 1G | ₹19800 | 2022-05-26 | Buy |
DRB Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
DRB is an inhibitor of RNA synthesis (causes premature termination of transcription).
Biochem/physiol Actions
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.
DRB Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 98)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Gagri Global IT Services Pvt. Ltd. | +91-40-27170174, | Telangana, India | 1321 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | China | 9980 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 11027 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
53-85-0(DRB)Related Search:
5,6-DICHLOROBENZIMIDAZOLE
5,6-DICHLORO-1-BETA-D-RIBOFURANOSYLBENZIMIDAZOLE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
(S)-3-AMINO-1,2-DIHYDROXYPROPANE HYDROCHLORIDE
1-HYDROXYMETHYLBENZIMIDAZOLE
BASIONIC(TM) AC 75
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5,6-DICHLOROPURINE-1-BETA-D-RIBOFURANOSYL-H-BENZIMIDAZOLE
5,6-DICHLORO-1-BETA-D-RIBOFURANOSYLBENZIMIDAZOLE
5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazol
5,6-dichlorobenzimidazoleriboside(drb)
Dichlorobenzimidazoleribofuranoside
dichlororibofuranosylbenzimidazole
5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole
5,6-Dichloropurine-1-b-D-ribofuanosyl-H-benzimidazole
DBR,5,6-Dichlorobenzimidazole1-b-D-ribofuranoside
5,6-dichloro-1-β-d-ribofuranosylbenzimidazole
5,6-dichlorobenzimidazole 1-β-d-ribofuranoside
5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB
5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE 98%
5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE (DRB)98%
5,6-Dichloropurine-1--D-ribofuanosyl-H-benzimidazole
DBR, 5,6-Dichlorobenzimidazole 1--D-ribofuranoside
5,6-Dichlorobenzimidazole-1-β-D-ribofuranoside ,98%
1-β-D-Ribofuranosyl-5,6-dichlorobenziMidazole
NSC 401575
4,5-dichloro-2-(3-methylbenzyl)pyridazin-3(2h)-one
5,6-DICHLOROBENZIMIDAZOLE-1-BETA-D-RIBOFURANOSIDE
5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE
5,6-DICHLORO-BETA-D-RIBOFURANOSYL-BENZIMIDAZOLE
DRB (Benzimidazole)
DRB
DBR
DRB USP/EP/BP
(2R,3R,4S,5R)-2-(5,6-Dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
5,6-DICHLOROBENIMIDAZOLE-1-B-D- RIBOFURANOSIDE
5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem
5,6-Dichlororibofuranosylbenzimidazole
5,6-Dichlorobenzimidazole1-β-D-Ribofuranoside>
5,6-Dichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole
1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl-
5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
5,6-Dichlorobenzimidazole riboside,DRB,inhibit,Inhibitor,CDK,Cyclin dependent kinase
5,6-Dichlorobenzimidazole riboside(DBR)
1H-Benzimidazole,5,6-dichloro-1-b-D-ribofuranosyl-
5,6-dichloro-1-β-D-ribobenzimidazole
,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
53-85-0
C12H12Cl2N2O4
DNA-RNA Transcription Regulators
Gene Regulation and Expression
Monosaccharides
Specialty Synthesis
BioChemical
Cell Biology
Carbohydrate Synthesis
Cell Signaling and Neuroscience
Bases & Related Reagents
Inhibitors
Nucleotides