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4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Structure
CAS No.
570407-42-0
Chemical Name:
4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine
Synonyms
Avatrapa impurity 10;Avatrombopag Impurity 47;Avatrombopag Impurity 13;Avatroposide impurities5;Avatroposide impurities19;2-Thiazolamine, 4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-;5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine4-(4-chlorothiophen-2-yl)-;4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine;4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-y1)thiazol-2-amine;4-(4-Chloro-thiophen-2-yl)-5-(4-cyclohexyl-piperazin-1-yl)-thiazol-2-ylamine
CBNumber:
CB04800390
Molecular Formula:
C17H23ClN4S2
Molecular Weight:
382.97
MOL File:
570407-42-0.mol
Modify Date:
2024/4/2 17:31:45

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Properties

Boiling point 560.0±50.0 °C(Predicted)
Density 1.345±0.06 g/cm3(Predicted)
pka 7.58±0.70(Predicted)

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Chemical Properties,Uses,Production

Uses

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is a valuable organic compound that could be used as an intermediate to synthesize thrombopoietin

Synthesis

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is synthesize from the reacton of 4- (4-Chloro-2-thienyl) -5-bromo-2-thiazolylamine with cyclohexylpiperazine. The reaction mixture was extracted with water and EtOAc. The combined organic phases were washed with distilled water and brine and dried to afford 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine.
4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Suppliers

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570407-42-0(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine)Related Search:

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine 2-Thiazolamine, 4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)- Avatrombopag Impurity 13 5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine4-(4-chlorothiophen-2-yl)- Avatrombopag Impurity 47 Avatroposide impurities19 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-y1)thiazol-2-amine 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine (Avatrombopag Impurity) Avatroposide impurities5 Avatrapa impurity 10 4-(4-Chloro-thiophen-2-yl)-5-(4-cyclohexyl-piperazin-1-yl)-thiazol-2-ylamine 570407-42-0 C17H23ClN4S2 Intermediate Intermediate