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Avatrombopag

Avatrombopag Structure
CAS No.
570406-98-3
Chemical Name:
Avatrombopag
Synonyms
Avatrombopag Base,Avatrombopag;AKR-501;Crenolanib Besylate;Avatrombopag (AKR-501);YM477;E 5501;AS 1670542;AVATROMBOPAG;AKR-501 USP/EP/BP;Avatrombopag Crude
CBNumber:
CB72522099
Molecular Formula:
C29H34Cl2N6O3S2
Molecular Weight:
649.65
MOL File:
570406-98-3.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:16
Request For Quotation

Avatrombopag Properties

Density 1.440
solubility DMSO:27.33(Max Conc. mg/mL);42.07(Max Conc. mM)
form A crystalline solid
pka 3.04±0.70(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P305+P351+P338-P310
NFPA 704
0
2 0

Avatrombopag Chemical Properties,Uses,Production

Description

Avatrombopag is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.It was the third thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia and the first approved to treat periprocedural thrombocytopenia in patients with chronic liver disease (thereby providing an alternative to blood transfusions for these patients). Avatrombopag was approved for medical use in the United States in 2018, and in the European Union in 2019.

Uses

Avatrombopag is used to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in people with chronic (ongoing) liver disease. It is also used to treat thrombocytopenia in people with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood).

Mechanism of action

Avatrombopag is in a class of medications called thrombopoietin (TPO) receptor agonists. It works by causing the body to produce more platelets.

target

TPO receptor

IC 50

IC 50 value is 3.3 nM.

Avatrombopag Preparation Products And Raw materials

Raw materials

4-(4-Chloro-2-thienyl)-2-thiazolamine

Preparation Products

Avatrombopag Suppliers

Global( 117)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Zison Pharmaceutical (Shandong) Co., Ltd. +86-0086-531-88259693 +86-18660188356 China 57 58 Inquiry
Shandong Risen-Sun Pharmaceutical Co., Ltd +86-15552509998 +86-15621883869 China 251 58 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2136 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49392 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24200 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Zison Pharmaceutical (Shandong) Co., Ltd. 58
Shandong Risen-Sun Pharmaceutical Co., Ltd 58
Zhejiang ZETian Fine Chemicals Co. LTD 58
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Dideu Industries Group Limited 58

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Avatrombopag Spectrum

Avatrombopag(570406-98-3)1HNMR

570406-98-3(Avatrombopag)Related Search:

Unii-4U07F515lg Eltrombopag Ibopamine Hydrochloride Lusutrombopag Lusutrombopag
methyl 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate Avatrombopag maleate 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine
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AVATROMBOPAG AS 1670542 E 5501 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]- Avatrombopag(AS1670542) 1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbo 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid AKR-501; YM477; E5501; AS 1670542 YM477 AKR-501 USP/EP/BP 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2 Crenolanib Besylate AKR-501 Avatrombopag (AKR-501) Avatrombopag Base,Avatrombopag 4- (2- (6- (4-carboxypyridine-1-yl) - (5-chloronicotinamide) -4- (4-chlorothienyl-2-yl) thiazol-5-yl) -1-cyclohexylpiperazine 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid (Avatrombopag Impurity) 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid Avatrombopag Monomer Avatrombopag Crude Avatrombopag Impurity(AKR 501) 570406-98-3 C29H34Cl2N6O3S2 Intermediate API