Tianeptine
- CAS No.
- 72797-41-2
- Chemical Name:
- Tianeptine
- Synonyms
- Tianeptin;TPI-1062;TIANEPTINE;JNJ-39823277;Einecs 276-851-9;72797-41-2;7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid;7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoic acid;(1)-7-((3-Chloro-6,11-dihydro-6-methyldibenzo(C,F)(1,2)thiazepin-11-yl)amino)heptanoic acid S,S-dioxide;(±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- CBNumber:
- CB0504881
- Molecular Formula:
- C21H25ClN2O4S
- Molecular Weight:
- 436.95
- MOL File:
- 72797-41-2.mol
- Modify Date:
- 2024/8/1 13:52:05
| Melting point | 129-131?C |
|---|---|
| Boiling point | 609.2±65.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| vapor pressure | 0.001Pa at 25℃ |
| storage temp. | Refrigerator, Under Inert Atmosphere |
| pka | 4.75±0.10(Predicted) |
| form | solid |
| InChIKey | JICJBGPOMZQUBB-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCCCCCNC1C2=CC=C(Cl)C=C2S(=O)(=O)N(C)C2=CC=CC=C21 |
| LogP | 2.162 at 25℃ and pH6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H362-H361-H373 |
| Precautionary statements | P201-P260-P263-P264-P270-P308+P313-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
| WGK Germany | 3 |
Tianeptine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. It is used mainly in the treatment of major depressive disorder and may also be used to treat anxiety, asthma, and irritable bowel syndrome. It has been found to act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors. Tianeptine prevents chronic stress-induced morphological changes in the hippocampus and amygdala and blocks the effects of acute stress on synaptic plasticity in the hippocampus and PFC.
brand name
Stablon, Tatinol, and Coaxil among others
Mechanism of action
Current research suggests that tianeptine produces its antidepressant effects through the modulation of glutamate receptor activity (for example, AMPA receptors and NMDA receptors) and affect the release of brain-derived neurotrophic factor (BDNF), which impacts neural plasticity.
Tianeptine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | China | 341 | 58 | Inquiry |
| Sigma Audley | +86-15937194204 +86-18126314766 | China | 491 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | China | 1069 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23555 | 58 | Inquiry |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | CHINA | 9427 | 58 | Inquiry |
| Hong Kong Excellence Biotechnology Co., Ltd. | China | 882 | 58 | Inquiry | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
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