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CHOLERA TOXIN

CHOLERA TOXIN Structure
CAS No.
9012-63-9
Chemical Name:
CHOLERA TOXIN
Synonyms
Cholergen;choleragen;CHOLERA TOXIN;Choleragenoid;choleraexotoxin;exo-enterotoxin;Toxins, cholera;CHOLERA ENTEROTOXIN;VIBRIO CHOLERAE TOXIN;choleraentero-exotoxin
CBNumber:
CB0683337
Molecular Formula:
NULL
Molecular Weight:
0
MOL File:
Mol file
Modify Date:
2024/7/2 8:54:58
Request For Quotation

CHOLERA TOXIN Properties

storage temp. 0-6°C
solubility H2O: soluble10mg/mL
form lyophilized powder
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300+H310-H332-H412
Precautionary statements  P262-P273-P280-P301+P310-P302+P352+P310-P304+P340+P312
Hazard Codes  T
Risk Statements  24/25-52/53
Safety Statements  36/37-45-61
RIDADR  3172
WGK Germany  2
RTECS  LF3100000
HazardClass  6.1
PackingGroup  I
Toxicity cholera toxin is secreted by the gram-negative bacterium Vibrio cholerae. It is a gastrointestinal toxin that increases adenylate cyclase activity of mucosa of the small intestine, thereby increasing cyclic AMP within these cells. Cyclic AMP stimulates active transport of ions by these epithelial cells, resulting in a large efflux of Na+ and water into the gut. The toxin enters cells by interacting with a GM1 ganglioside on the cell surface. After entry, the A1 subunit catalyzes the transfer of an ADP-ribose unit from NAD+ to an arginine side chain of the adenylate cyclase regulatory G protein, blocking its GTPase activity. Thus the adenylate cyclase deactivation mechanism is destroyed, and cyclic AMP is continually produced. The major sign of cholera poisoning is severe diarrhea; several liters of body water may be lost within a few hours, leading to shock and death if fluid is not replaced. Treatment involves physiological support (including i.v. fluids) and antibiotics.

CHOLERA TOXIN price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C8052 Cholera Toxin from Vibrio cholerae ≥90% (SDS-PAGE), lyophilized powder 9012-63-9 0.5MG ₹16627.8 2022-06-14 Buy
Sigma-Aldrich(India) C8052 Cholera Toxin from Vibrio cholerae ≥90% (SDS-PAGE), lyophilized powder 9012-63-9 1MG ₹27650.1 2022-06-14 Buy
Sigma-Aldrich(India) C8052 Cholera Toxin from Vibrio cholerae ≥90% (SDS-PAGE), lyophilized powder 9012-63-9 2MG ₹50038.8 2022-06-14 Buy
Product number Packaging Price Buy
C8052 0.5MG ₹16627.8 Buy
C8052 1MG ₹27650.1 Buy
C8052 2MG ₹50038.8 Buy

CHOLERA TOXIN Chemical Properties,Uses,Production

Uses

Cholera Toxin from Vibrio cholerae has been used as a positive control in cAMP (cyclic AMP) assay for enterotoxins. It has been added as a supplement in cell culture media of primary tumors and epithelial cells.

Biochem/physiol Actions

Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.

CHOLERA TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

CHOLERA TOXIN Suppliers

Global( 46)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 China 33350 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 18112977050 China 10529 58 Inquiry
MedChemExpress 021-58955995 United States 6398 58 Inquiry
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 China 29778 58 Inquiry
Portail Substances Chimiques 10 20 0000 France 6027 58 Inquiry
Hubei Enxing Biotechnology Co., Ltd 16621771607 China 8329 58 Inquiry
G-CLONE 400-910-1997 17560619001 China 9959 58 Inquiry
Beijing OKA biological technology co., LTD 010-010-62971590 18548936886 China 6912 58 Inquiry
Supplier Advantage
Career Henan Chemica Co 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58
Aladdin Scientific 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 58
MedChemExpress 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Portail Substances Chimiques 58
Hubei Enxing Biotechnology Co., Ltd 58
G-CLONE 58
Beijing OKA biological technology co., LTD 58

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Choleragenoid Cholera Toxin from Vibrio cholerae,Cholera enterotoxin, Cholergen Cholergen CHOLERA TOXIN CHOLERA ENTEROTOXIN CHOLERA TOXIN, VIBRIO CHOLERAE, TYPE INABA 569B VIBRIO CHOLERAE TOXIN choleraentero-exotoxin choleraexotoxin choleragen exo-enterotoxin exotoxin,vibriocholerae CHOLERA TOXIN FROM VIBRIO CHOLERAE Toxins, cholera 9012-63-9 G Protein Function G Proteins and Cyclic Nucleotides Reagents BioChemical Cell Signaling and Neuroscience Cell Biology