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NIKKOMYCIN Z

CAS No.: 59456-70-1

Chemical Name:: NIKKOMYCIN Z

Synonyms: NIKKOMYCIN;huaguamycin;neopolyoxinc;NIKKOMYCIN Z;(2s-(2r*,3r*,4r*))-l);NIKKOMYCIN Z, STREPTOMYCES TENDAE;Nikkomycin Z, Sterptomyces tendae;nikkomycin Z from streptomyces tendae;5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci;5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid

CBNumber:: CB0767000

Molecular Formula:: C20H25N5O10

Molecular Weight:: 495.44

MOL File:: 59456-70-1.mol

Modify Date:: 2024/7/2 8:54:58

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NIKKOMYCIN Z Properties

Density	1.646±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H2O: soluble5mg/mL
form	Solid
pka	2.70±0.10(Predicted)
color	White to off-white
Water Solubility	Water : ≥ 100 mg/mL (201.84 mM)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H315-H319
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	BA2928200
F	10

NIKKOMYCIN Z price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	N8028	Nikkomycin Z from Streptomyces tendae ≥90% (HPLC)	59456-70-1	5MG	₹26726.93	2022-06-14	Buy

Product number	Packaging	Price	Buy
N8028	5MG	₹26726.93	Buy

NIKKOMYCIN Z Chemical Properties,Uses,Production

Description

Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.

Uses

Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.

Definition

ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.

Pharmacology

By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.

Metabolism

There are no detailed reports on metabolism/transformation of nikkomycins in the environment.

NIKKOMYCIN Z Preparation Products And Raw materials

Raw materials

Preparation Products

NIKKOMYCIN Z Suppliers

Global( 45)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15416	58	Inquiry
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	China	9642	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49734	58	Inquiry
TargetMol Chemicals Inc.		United States	38642	58	Inquiry
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618501500038	China	26362	58	Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618791163155	China	3558	58	Inquiry
Aladdin Scientific		United States	52924	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9835	58	Inquiry
MedChemExpress	021-58955995	United States	6398	58	Inquiry
Nantong Zhonghe Chemical New Materials Co., Ltd	13003551299 15950816326	China	9173	58	Inquiry

Supplier	Advantage
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Aladdin Scientific	58
RD International Technology Co., Limited	58
MedChemExpress	58
Nantong Zhonghe Chemical New Materials Co., Ltd	58

Mechanism of action of Nikkomycin Z
Nikkomycin Z is an experimental compound with antifungal properties. Like all nikkomycins, it consists of a pyrimidine nucleos....
Mar 31，2022

59456-70-1(NIKKOMYCIN Z)Related Search:

NIKKOMYCIN Z PROPYL-(TETRAHYDRO-FURAN-2-YLMETHYL)-AMINE D-HOMOCITRULLINE (S)-(+)-Tetrahydrofurfurylamine GLYCYL-D-THREONINE DIHYDRATE

AC-D-NLE-OH GLYCYL-D-SERINE (2R,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID 4-PYRIDIN-2-YL-BUTYLAMINE Nikkomycin M

dl-3-hydroxynorvaline AC-D-LYS-OH GLYCYL-D-THREONINE Nikkomycin N Nikkomycin J

Nikkomycin pseudo-J nikkomycin L(z) nikkomycin L(x)

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NIKKOMYCIN NIKKOMYCIN Z NIKKOMYCIN Z, STREPTOMYCES TENDAE (2s-(2r*,3r*,4r*))-l) 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidiny neopolyoxinc nikkomycin Z from streptomyces tendae Nikkomycin Z, Sterptomyces tendae 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid 5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid β-D-Allofuranuronic acid, 5-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)- huaguamycin 59456-70-1 C20H25N5O10 BioChemical Antibiotics Antibiotics A to Z Antibiotics N-S AntifungalGlycobiology InhibitorsAntibiotics Peptidyl NucleosidesMore...Close... Inhibitors and Substrates Peptidyl Nucleosides Antibiotics Antibiotics A to Antibiotics N-SAntibiotics AntifungalAntibiotics Chemical Structure Class Inhibits an EnzymeAntibiotics Interferes with Cell Wall SynthesisAntibiotics Mechanism of Action Spectrum of Activity