bicozamycin
- CAS No.
- 38129-37-2
- Chemical Name:
- bicozamycin
- Synonyms
- C11259;WS-4545;ICOZAMYCIN;bicozamycin;BicycloMycin;BicozaMycin benzoate;BicozaMycin, AizuMycin, Bacteron, CGP 3543E, WS4545, 5879;(1R,6S)-1-hydroxy-2-methylidene-6-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-5-oxa-8,10-diazabicyclo[4.2.2]decane-7,9-dione;2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6R)-
- CBNumber:
- CB0895983
- Molecular Formula:
- C12H18N2O7
- Molecular Weight:
- 302.28
- MOL File:
- 38129-37-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 15:13:57
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Toxicity | LD50 in mice: >4 g/kg (Williams, Durham) |
bicozamycin Chemical Properties,Uses,Production
Uses
Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites. The primary site of action for bicyclomycin is thought to be the rho transcription termination factor.
Definition
ChEBI: A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.
Origin
Bicozamycin, formerly called bicyclomycin, was found independently in 1972, in the cul ture broth of Streptomyces sapporonensisbyFu jisawa Pharmaceuticals Industries and in that of S. aizuensis by Miyamura et al. of Ni igata University.
Biological Activity
Bicozamycin has a unique bicyclic structure and shows activity against Kleb siella, Salmonella, and Shigella but noneagainst other gram-negative bacteria or gram-positive microorganisms.
Safety
Bicozamycin is not absorbed orally and showsverylowtoxicity;nomicedied following its intravenous injection at a dose as high as two grams per kilogram.
bicozamycin Preparation Products And Raw materials
Raw materials
Preparation Products
bicozamycin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | China | 30968 | 58 | Inquiry |
| Lynnchem | 86-(0)29-85992781 17792393971 | China | 4587 | 58 | Inquiry |
| Shanghai Yanchun Biopharmaceutical Technology Co., Ltd | 4001-009266 17349750668 | China | 2811 | 58 | Inquiry |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | China | 3705 | 58 | Inquiry |
| Hubei Enxing Biotechnology Co., Ltd | 16621771607 | China | 8322 | 58 | Inquiry |