Rutamycin
- CAS No.
- 1404-59-7
- Chemical Name:
- Rutamycin
- Synonyms
- A-272;RR-32705;Rutamycin;RRNo-32705;oligomycin D;26-Demethyloligomycin A;RutaMycin, 26-deMethyloligoMycin A, A 272, RR 32705, RutaMycin A;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-,(1S,2'R,4E,5'S,6S,6'S,7S,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-, (1S,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-
- CBNumber:
- CB11120704
- Molecular Formula:
- C44H72O11
- Molecular Weight:
- 777.042
- MOL File:
- 1404-59-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/21 10:59:17
| Melting point | 116-119° |
|---|---|
| alpha | D20 -62° (c = 1.36 in CHCl3) |
| Boiling point | 883.4±65.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble |
| form | A lyophilisate |
| pka | 12.52±0.70(Predicted) |
SAFETY
Risk and Safety Statements
| RIDADR | 2811 |
|---|---|
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 oral in mouse: 800mg/kg |
Rutamycin Chemical Properties,Uses,Production
Description
Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 μM.
Uses
Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
Rutamycin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | China | 2972 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28091 | 58 | Inquiry |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | China | 24998 | 58 | Inquiry |
| Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 | China | 9849 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8739 | 58 | Inquiry |