Sildenafil Chlorosulfonyl

CAS No.: 139756-22-2

Chemical Name:: Sildenafil Chlorosulfonyl

Synonyms: Sildenafil Impurity 7;Methisosildenafil-004;Sildenafil　intermediate;Sildenafil Chlorosulfone;Sildenafil chlorosulfonyl;Methisosildenafil Impurity 33;Sildenafil Chlorosulfone IMpurity;Sildenafil Chlorosulfonyl IMpurity;5-(5-CHLORO SULFONYL-2-ETHOXY PHENYL)-1-;4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro

CBNumber:: CB11175931

Molecular Formula:: C17H19ClN4O4S

Molecular Weight:: 410.88

MOL File:: 139756-22-2.mol

MSDS File:: SDS

Modify Date:: 2023/9/4 17:31:24

Request For Quotation

Sildenafil Chlorosulfonyl Properties

Melting point	180-182°C
Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	9.87±0.20(Predicted)
color	White to Pale Beige
Stability	Moisture Sensitive
InChI	InChI=1S/C17H19ClN4O4S/c1-4-6-12-14-15(22(3)21-12)17(23)20-16(19-14)11-9-10(27(18,24)25)7-8-13(11)26-5-2/h7-9H,4-6H2,1-3H3,(H,19,20,23)
InChIKey	RVVOSOSBFSYZDM-UHFFFAOYSA-N
SMILES	C1(S(Cl)(=O)=O)=CC=C(OCC)C(C2NC(=O)C3N(C)N=C(CCC)C=3N=2)=C1
CAS DataBase Reference	139756-22-2

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P301+P330+P331-P303+P361+P353

HS Code

2933599590

NFPA 704

	0
2		0

Sildenafil Chlorosulfonyl Chemical Properties,Uses,Production

Description

Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor sildenafil. It is also a potential impurity found in commercial preparations of sildenafil.

Chemical Properties

Off-White Solid

Uses

The compound Sildenafil Chlorosulfonyl Impurity (139756-22-2) is a derivative of Sildenafil. It is widely used in the treatment of pulmonary hypertension as it is capable of inhibiting cGMP and acts as a potent selective inhibitor of PDE5.

Sildenafil Chlorosulfonyl Preparation Products And Raw materials

Raw materials

Preparation Products

Hydroxyhomosildenafil

Sildenafil Chlorosulfonyl Suppliers

Global( 168)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Molkem Chemicals	+91-917228022464 +91-7228022464	Ahmedabad, India	138	58	Inquiry
Bhausa Life Sciences	+91-8154986830 +91-8154986830	Gujarat, India	201	58	Inquiry
SAG Chem	+91-9819395336 +91-9819395336	Mumbai, India	17	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
Lakshmi Farmachem	+91-9948795885 +91-9550886476	Telangana, India	407	58	Inquiry
Allmpus Laboratories Pvt Ltd	+91-9518738415 +91-9167862134	Maharashtra, India	657	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6514	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8467	58	Inquiry

Supplier	Advantage
Molkem Chemicals	58
Bhausa Life Sciences	58
SAG Chem	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
Lakshmi Farmachem	58
Allmpus Laboratories Pvt Ltd	58
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

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3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1 H-pyrazolo-(4-3-d)-pyrimidine-5 3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 5-(5-CHLOROSULFONYL-2-ETHOXY PHENYL)-1-METHYL-3-N-PROPYL-1 Sildenafil Chlorosulfonyl IMpurity 4-Ethoxy-3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyriMidin-5-yl)benzene-1-sulfonyl chloride Sildenafil Chlorosulfone IMpurity 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo-[4,3-d]pyrimidin-5-yl)benzene-1-sulfo 4-Ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride Sildenafil　intermediate 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl) 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo-[4,3-d]pyrimidin-5-yl)benzene-1-su Sildenafil Impurity 7 Methisosildenafil-004 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one Sildenafil impurity 33/Sildenafil Chlorosulfonyl/Sildenafil Chlorosulfone Impurity/5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro 5-(5-CHLORO SULFONYL-2-ETHOXY PHENYL)-1- 5-(5-CHLORO SULFONYL-2-ETHOXY PHENYL)-1- METHYL-3-PROPYL-1 6-DIHYDRO-7H-PYRAZOL O-(4 3-D)PYRIMIDINE-7-ONE Methisosildenafil Impurity 33 Benzenesulfonyl chloride, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy- Demethylpiperazinyl sildenafil sulfonyl chloride 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride 5-(5-CHLORO SULFONYL-2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO-[4,3,D]-PYRIMIDINE-7-ONE 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-Chemicalbookpropyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-di... Sildenafil Chlorosulfone Sildenafil chlorosulfonyl 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo4,3-dpyrimidin-5-yl)benzene-1-sulfonyl chloride 4-Ethoxy-3-(1-methy1-7-oxo~3-propy1-6,7-diliydro-lH-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-suIfonyl cliloride Sildenafil Chlorosulfone Impurity / Sildenafil Chlorosulfone / Sildenafil Chlorosulfonyl Impurity Sildenafil Chlorosulfonyl (5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyra 139756-22-2 Bases & Related Reagents Nucleotides Sulfonyl Chlorides