GRANZYME B
- CAS No.
- 143180-74-9
- Chemical Name:
- GRANZYME B
- Synonyms
- GZMB;GRANZYME B;EC 3.4.21.79;GRANZYME B ENZYME;GRANZYME B (HUMAN);Granzyme B from mouse;Granzyme B from Mouse, Recombinant;Granzyme B from Human, Recombinant;Recombinant Mouse Gzmb Protein, His Tag;SensiZyme Granzyme B Activity Assay Kit
- CBNumber:
- CB1120279
- Molecular Formula:
- Molecular Weight:
- 0
- MOL File:
- Mol file
- Modify Date:
- 2023/4/23 13:52:06
GRANZYME B Chemical Properties,Uses,Production
General Description
Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations.
Biochem/physiol Actions
Cytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way.
GRANZYME B Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
| A.G. Scientific, Inc. | 858 452 9925 | United States | 1066 | 71 | Inquiry |
| Alexis Corporation | +41 61 926 8989 | Switzerland | 3599 | 74 | Inquiry |
| BIOMOL INTERNATIONAL, LP | (800) 942-0430 | United States | 1503 | 77 | Inquiry |
| Kamiya Biomedical Company | 206 575 8068 | United States | 736 | 72 | Inquiry |
| Wako Pure Chemical Industries, Ltd. | +81 6 6203 3741 | Japan | 6828 | 80 | Inquiry |
| Kanto Chemical Co., Inc. | +81 3 3663 7631 | Japan | 6762 | 74 | Inquiry |
| EMD Biosciences, Inc. | 858 450 5500 | United States | 6529 | 66 | Inquiry |
| Fluorochem Ltd. | +44 1457 868921 | United Kingdom | 6406 | 74 | Inquiry |
| VWR International | 800 932 5000 | United Kingdom | 6554 | 82 | Inquiry |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| A.G. Scientific, Inc. | 71 |
| Alexis Corporation | 74 |
| BIOMOL INTERNATIONAL, LP | 77 |
| Kamiya Biomedical Company | 72 |
| Wako Pure Chemical Industries, Ltd. | 80 |
| Kanto Chemical Co., Inc. | 74 |
| EMD Biosciences, Inc. | 66 |
| Fluorochem Ltd. | 74 |
| VWR International | 82 |
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