Chinese english Japanese Germany Korea

macbecin I

macbecin I Structure
CAS No.
73341-72-7
Chemical Name:
macbecin I
Synonyms
Macbecin;macbecin I;(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin;(6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin;Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)-
CBNumber:
CB11346962
Molecular Formula:
C30H42N2O8
Molecular Weight:
558.67
MOL File:
73341-72-7.mol
Modify Date:
2023/5/18 11:30:59
Request For Quotation

macbecin I Properties

Melting point 205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point 736.2±60.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
storage temp. Desiccate at -20°C
solubility Soluble in DMSO > 10 mM
form Powder
pka 8.62±0.70(Predicted)

macbecin I Chemical Properties,Uses,Production

Uses

Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity.

Biological Activity

Ansamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ).

macbecin I Preparation Products And Raw materials

Raw materials

Preparation Products

macbecin I Suppliers

Global( 23)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
ApexBio Technology + 1-832-696-8203 United States 6254 58 Inquiry
Shanghai Weiwei Biological Technology Co., Ltd. 021-55669583 18616258598 CHINA 4398 58 Inquiry
Shanghai Haoyang Biological Technology Co., Ltd. 021-54046790 15121098156 CHINA 2905 58 Inquiry
Beijing Taize Ruida Technology Co., Ltd. 400-800-8151 13651185998 CHINA 6536 58 Inquiry
Shanghai Chaoyan Biotechnology Co., Ltd. 021-50840550 CHINA 6217 58 Inquiry
Boao Pike 010-57798038 15652371397 CHINA 6629 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Cayman Chemical Company 81
Tocris Bioscience 77
ApexBio Technology 58
Shanghai Weiwei Biological Technology Co., Ltd. 58
Shanghai Haoyang Biological Technology Co., Ltd. 58
Beijing Taize Ruida Technology Co., Ltd. 58
Shanghai Chaoyan Biotechnology Co., Ltd. 58
Boao Pike 58

73341-72-7(macbecin I)Related Search:

N-DECYL METHACRYLAMIDE macbecin I
macbecin I (6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)- Macbecin 73341-72-7