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8-hydroxyloxapine

8-hydroxyloxapine Structure
CAS No.
61443-77-4
Chemical Name:
8-hydroxyloxapine
Synonyms
8-hydroxyloxapine;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
CBNumber:
CB11370570
Molecular Formula:
C18H18ClN3O2
Molecular Weight:
343.81
MOL File:
61443-77-4.mol
Modify Date:
2023/6/8 9:03:09
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8-hydroxyloxapine Properties

Melting point 212-215°C
storage temp. Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility DMSO: soluble
form A solid
Stability Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
NFPA 704
0
3 0

8-hydroxyloxapine Chemical Properties,Uses,Production

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).

Chemical Properties

Pale Yellow Solid

Uses

The inactive

8-hydroxyloxapine Preparation Products And Raw materials

Raw materials

Preparation Products

8-hydroxyloxapine Suppliers

Global( 14)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Toronto Research Chemicals +1 (416) 665-9696 Canada 6088 71 Inquiry
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 China 96815 76 Inquiry
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 China 56070 58 Inquiry
United States Biological 1-800-520-3011 United States 6106 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 China 7980 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8739 58 Inquiry
BOC Sciences 1-631-485-4226; 16314854226 United States 14059 65 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28091 58 Inquiry
Supplier Advantage
Toronto Research Chemicals 71
J & K SCIENTIFIC LTD. 76
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
United States Biological 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
BOC Sciences 65
TargetMol Chemicals Inc. 58

61443-77-4(8-hydroxyloxapine)Related Search:

8-METHOXY LOXAPINE 2-METHOXY-BENZAMIDINE HCL 1-(3-CHLOROBENZYL)PIPERAZINE 1-(2-METHOXYBENZYL) PIPERAZINE 4-(4-Chlorophenoxy)phenol
8-hydroxyloxapine CHEMBRDG-BB 4022460 Dibenz-(b,f)-1,4-oxazephine Amoxapine 1-(2-PHENOXYPHENYL)METHANAMINE HYDROCHLORIDE
2-Hydroxy-benzamidine HCl loxapine
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8-hydroxyloxapine 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)- Loxapine 8-Hydroxy Impurity 61443-77-4 Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals