8-hydroxyloxapine

- CAS No.
- 61443-77-4
- Chemical Name:
- 8-hydroxyloxapine
- Synonyms
- 8-hydroxyloxapine;8-Hydroxy Loxapine solution;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
- CBNumber:
- CB11370570
- Molecular Formula:
- C18H18ClN3O2
- Molecular Weight:
- 343.81
- MOL File:
- 61443-77-4.mol
- Modify Date:
- 2025/1/27 9:38:02
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302+H312+H332-H315-H319 | |||||||||
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501 | |||||||||
NFPA 704 |
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8-hydroxyloxapine Chemical Properties,Uses,Production
Description
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
Chemical Properties
Pale Yellow Solid
Uses
The inactive
8-hydroxyloxapine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 21)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32159 | 58 | Inquiry |
Cato Research Chemicals Inc. | 18933936954 | China | 17709 | 58 | Inquiry |
Absin Bioscience Inc. | 021-38015121-8802 | CHINA | 6208 | 58 | Inquiry |
Neobioscience Co., Ltd. | 4006-800-892 | CHINA | 6207 | 58 | Inquiry |
Cayman Chemical Company | 800-364-9897 | China | 21645 | 58 | Inquiry |
Aikon International Limited | 18651614124 | China | 9199 | 58 | Inquiry |
Merck KGaA | 21-20338288 | China | 292394 | 58 | Inquiry |
Shanghai Haohong Scientific Co., Ltd. | 400-8210725 4008210725 | China | 38811 | 58 | Inquiry |
Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | China | 233051 | 58 | Inquiry |
Toronto Research Chemicals | +1 (416) 665-9696 | Canada | 6038 | 71 | Inquiry |
61443-77-4(8-hydroxyloxapine)Related Search:
8-hydroxyloxapine
2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol
Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
Loxapine 8-Hydroxy Impurity
8-Hydroxy Loxapine solution
61443-77-4
Heterocycles
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals