8-hydroxyloxapine

8-hydroxyloxapine Structure
CAS No.
61443-77-4
Chemical Name:
8-hydroxyloxapine
Synonyms
8-hydroxyloxapine;8-Hydroxy Loxapine solution;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
CBNumber:
CB11370570
Molecular Formula:
C18H18ClN3O2
Molecular Weight:
343.81
MOL File:
61443-77-4.mol
Modify Date:
2025/1/27 9:38:02

8-hydroxyloxapine Properties

Melting point 212-215°C
storage temp. Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility DMSO: soluble
form A solid
Stability Light Sensitive

SAFETY

Risk and Safety Statements

8-hydroxyloxapine Chemical Properties,Uses,Production

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).

Chemical Properties

Pale Yellow Solid

Uses

The inactive

8-hydroxyloxapine Preparation Products And Raw materials

Raw materials

Preparation Products

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8-hydroxyloxapine 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)- Loxapine 8-Hydroxy Impurity 8-Hydroxy Loxapine solution 61443-77-4 Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals