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8-hydroxyloxapine

8-hydroxyloxapine Structure
CAS No.
61443-77-4
Chemical Name:
8-hydroxyloxapine
Synonyms
8-hydroxyloxapine;8-Hydroxy Loxapine solution;Loxapine 8-Hydroxy Impurity;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-
CBNumber:
CB11370570
Molecular Formula:
C18H18ClN3O2
Molecular Weight:
343.81
MOL File:
61443-77-4.mol
Modify Date:
2025/1/27 9:38:02
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8-hydroxyloxapine Properties

Melting point 212-215°C
storage temp. Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility DMSO: soluble
form A solid
Stability Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
NFPA 704
0
3 0

8-hydroxyloxapine Chemical Properties,Uses,Production

Description

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).

Chemical Properties

Pale Yellow Solid

Uses

The inactive

8-hydroxyloxapine Preparation Products And Raw materials

Raw materials

Preparation Products

8-hydroxyloxapine Suppliers

Global( 21)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Cato Research Chemicals Inc. 18933936954 China 17709 58 Inquiry
Absin Bioscience Inc. 021-38015121-8802 CHINA 6208 58 Inquiry
Neobioscience Co., Ltd. 4006-800-892 CHINA 6207 58 Inquiry
Cayman Chemical Company 800-364-9897 China 27736 58 Inquiry
Aikon International Limited 18651614124 China 9199 58 Inquiry
Merck KGaA 21-20338288 China 292394 58 Inquiry
Shanghai Haohong Scientific Co., Ltd. 400-8210725 4008210725 China 38811 58 Inquiry
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 China 233051 58 Inquiry
Toronto Research Chemicals +1 (416) 665-9696 Canada 6038 71 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Cato Research Chemicals Inc. 58
Absin Bioscience Inc. 58
Neobioscience Co., Ltd. 58
Cayman Chemical Company 58
Aikon International Limited 58
Merck KGaA 58
Shanghai Haohong Scientific Co., Ltd. 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Toronto Research Chemicals 71

61443-77-4(8-hydroxyloxapine)Related Search:

8-METHOXY LOXAPINE 2-METHOXY-BENZAMIDINE HCL 1-(3-CHLOROBENZYL)PIPERAZINE 1-(2-METHOXYBENZYL) PIPERAZINE 4-(4-Chlorophenoxy)phenol
8-hydroxyloxapine CHEMBRDG-BB 4022460 Dibenz-(b,f)-1,4-oxazephine Amoxapine 1-(2-PHENOXYPHENYL)METHANAMINE HYDROCHLORIDE
2-Hydroxy-benzamidine HCl loxapine
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8-hydroxyloxapine 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)- Loxapine 8-Hydroxy Impurity 8-Hydroxy Loxapine solution 61443-77-4 Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals