Somatotropin
- CAS No.
- 12629-01-5
- Chemical Name:
- Somatotropin
- Synonyms
- HGH;SOMATROPIN;GH;GROWTH HORMONE;Genotropin;HUMAN GROWTH HORMONE;Omnitrope;SOMATOTROPIN;humatrope;norditropin
- CBNumber:
- CB1151396
- Molecular Formula:
- C990H1529N263O299S7
- Molecular Weight:
- 22124.12
- MOL File:
- Mol file
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 17:49:17
| alpha | 25 -38.7° (0.1M acetic acid) |
|---|---|
| storage temp. | 2-8°C |
| form | lyophilized powder |
| CAS DataBase Reference | 12629-01-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS07,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H317-H361-H332-H312 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P201-P202-P281-P308+P313-P405-P501 |
| Hazard Codes | B |
| WGK Germany | 3 |
| RTECS | TO7385000 |
| HS Code | 2937110000 |
| Toxicity | LD50 oral in rat: 160iu/kg |
Somatotropin Chemical Properties,Uses,Production
Description
Somatotropin, a second-generation (methionine-free) human growth hormone produced by recombinant technology, was launched in the U.S.A. for the treatment of growth failure in children due to chronic renal insufficiency before transplantation and for the long term treatment of short stature in children with growth failure due to a lack of endogenous growth hormone secretion. The efficacy of somatotropin is reportedly comparable to the first biosynthetic growth hormone somatrem, which contains a methionyl residue, but with less frequent antibody formation and rarely causes allergic effects or impairs growth response. Somatotropin is also in clinical trials for the treatment of growth hormone deficiency in adults and is currently under approval review for Turner's syndrome.
Chemical Properties
White or almost white powder.
World Health Organization (WHO)
Somatropin, a pituitary-derived human growth hormone, has been used in the treatment of hypopituitary dwarfism for over twenty years. In 1985 it became known that Creutzfeldt-Jakob disease, a potentially fatal form of brain degeneration resulting from a slow neurotropic viral infection, had developed in several patients who had received preparations of somatropin in the late 1960s/early 1970s. This led to the withdrawal of these preparations in many countries. An international collaborative effort was maintained to identify newlydiagnosed cases. By 1990 a total of 30 such cases had been notified. More efficient purification procedures introduced during the 1970s greatly reduced the risk of viral contamination, but products containing pituitary-derived somatropin have been superseded by biosynthetically-manufactured preparations produced using recombinant techniques.
General Description
Somatropin for injection(Humatrope) is a natural-sequence human GH of rDNAorigin. Its composition and sequence of amino acids areidentical with those of human GH of pituitary origin. It isadministered intramuscularly or subcutaneously. Thedosage range is 0.05 to 0.1 IU.
Clinical Use
Human Growth Hormone (Somatotropin) is a protein that is essential for normal growth and developmentin humans. Human Growth Hormone(hGH) affects many aspects of humandevelopment and metabolism including longitudinalgrowth, regulation (increase) of protein synthesis and lipolysis,and regulation (decrease) of glucose metabolism. Human Growth Hormone(hGH)has been used as a drug since the 1950s, and it has been extremelysuccessful in the treatment of classic growth hormonedeficiency, chronic renal insufficiency, Turner syndrome,failure to lactate in women, and Prader-Willisyndrome. In its long history, the hormone has been remarkablysuccessful and free of side effects.
Side effects
Carpal tunnel syndrome.
Increased insulin resistance.
Type 2 diabetes.
Swelling in the arms and legs (edema).
Joint and muscle pain.
For men, enlargement of breast tissue (gynecomastia).
Increased risk of certain cancers.
Somatotropin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Kapil Enterprises | 08047301824 | Delhi, India | 6 | 58 | Inquiry |
| Immune Ultimate Food Supplement | 08048979433 | Uttar Pradesh, India | 10 | 58 | Inquiry |
| Fitness Hub | 08047622875 | Punjab, India | 4 | 58 | Inquiry |
| Heet Healthcare Private Limited | 08048372509Ext 317 | Ahmedabad, India | 3 | 58 | Inquiry |
| Elikem Pharmaceuticals Private Limited | 08048250317Ext 783 | Gujarat, India | 1 | 58 | Inquiry |
| Powerhouse Nutritions Private Limited | 08048951600 | Haryana, India | 10 | 58 | Inquiry |
| Mehadia Tradelinks | 08048250284Ext 747 | Mumbai, India | 6 | 58 | Inquiry |
| Ronak Alkalies And Chemicals Private Limited | 08048372180Ext 358 | Gujarat, India | 11 | 58 | Inquiry |
Related articles
- Physiologic Basis of Somatotropin and Its Clinical Applications
- Somatotropin stimulates ovarian function, improves reproductive outcomes in assisted reproductive technology, and enhances ooc....
- Jan 22，2024
- Bioactivity of Human Growth Hormone
- Human Growth Hormone (HGH) is composed of growth hormones naturally found in bacteria that are linked to signaling peptides.
- Nov 22，2022
12629-01-5(Somatotropin)Related Search:
1of4
chevron_right