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Fosaprepitant

Fosaprepitant Structure
CAS No.
172673-20-0
Chemical Name:
Fosaprepitant
Synonyms
L 758298;Fosaprepitant;Fosaprepitant D4;MK-0517 (Fosaprepitant);Fosaprepitant See F727305;Fosaprepitant (See also F727305);[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-2H-1,2,4-triazol-1-yl]phosphonic acid;[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid;P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid;Phosphonic acid, P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-
CBNumber:
CB11515191
Molecular Formula:
C23H22F7N4O6P
Molecular Weight:
614.41
MOL File:
172673-20-0.mol
MSDS File:
SDS
Modify Date:
2024/6/12 17:09:27
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Fosaprepitant Properties

Melting point >74°C (dec.)
Density 1.65
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO, Methanol
pka 2.45±0.20(Predicted)
form Solid
color White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Fosaprepitant Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.

Definition

ChEBI: A morpholine derivative that is the (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl ether of (3-{[(2R,3S)-3-(4-fluorophenyl)-2-hydroxymorpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triaz l-1-yl)phosphonic acid.

Fosaprepitant Preparation Products And Raw materials

Raw materials

Preparation Products

Fosaprepitant Suppliers

Global( 124)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SURYA LIFE SCIENCES LIMITED +91-2646226290 +91-9428511112 Gujarat, India 62 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
Glenmark Pharmaceuticals Limited +912240189999 Maharashtra, India 93 58 Inquiry
Moleculochem 9811853366 New Delhi, India 25 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Shreyaa Medilife Private Limited +91-6354474696 +91-9879513108 Ahmedabad, India 67 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Supplier Advantage
SURYA LIFE SCIENCES LIMITED 58
Dr. Reddy's Laboratories Ltd 58
Glenmark Pharmaceuticals Limited 58
Moleculochem 58
Ralington Pharma 58
Shreyaa Medilife Private Limited 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58

Fosaprepitant Spectrum

Fosaprepitant(172673-20-0)1HNMR

172673-20-0(Fosaprepitant)Related Search:

Dimethomorph Moroxydine Diphenyl ether PHENYL VALERATE Piracetam
Moroxydine hydrochloride Zolpidem tartrate Voriconazole PHENYL RESIN fosaprepitant dibenzyl ester
Fosaprepitant Benzyl Ester Fosaprepitant dimeglumine Diphosphoric acid, tris(phenylmethyl) ester (9CI) Aprepitant Fosaprepitant Impurity 14
Fosaprepitant Impurity 17 Fosaprepitant Impurity 11 Fosaprepitant Impurity 9
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[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-2H-1,2,4-triazol-1-yl]phosphonic acid [3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid L 758298 P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid MK-0517 (Fosaprepitant) D-Glucitol, 1-deoxy-1-(MethylaMino)-, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4- Morpholinyl)Methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate (2:1) Fosaprepitant Fosaprepitant (See also F727305) Phosphonic acid, P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]- Fosaprepitant See F727305 Fosaprepitant D4 172673-20-0 C23H22F7N4O6P Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals