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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >HDAC inhibitors >ITF2357

ITF2357

ITF2357 Structure
CAS No.
732302-99-7
Chemical Name:
ITF2357
Synonyms
ITF2357;CS-1443;ITF2357 (Givinostat);Givinostat(HCl hydrate);Givinostat Hydrochloride Hydrate;Givinostat (ITF2357) 732302-99-7;ITF2357 hydrochloride monohydrate;Givinostat (ITF2357) HCl monohydrate;Gavinostat hydrochloride monohydrate;Givinostat HCl monohydrate (ITF-2357
CBNumber:
CB12561481
Molecular Formula:
C24H30ClN3O5
Molecular Weight:
475.9651
MOL File:
732302-99-7.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:01:59
Request For Quotation

ITF2357 Properties

storage temp. -20°C
solubility ≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
form powder
color white to beige
CAS DataBase Reference 732302-99-7

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
NFPA 704
0
2 0

ITF2357 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1772 Givinostat hydrochloride hydrate ≥95% (HPLC) 732302-99-7 5MG ₹13888.48 2022-06-14 Buy
Sigma-Aldrich(India) SML1772 Givinostat hydrochloride hydrate ≥95% (HPLC) 732302-99-7 25MG ₹55727.1 2022-06-14 Buy
Product number Packaging Price Buy
SML1772 5MG ₹13888.48 Buy
SML1772 25MG ₹55727.1 Buy

ITF2357 Chemical Properties,Uses,Production

Uses

Givinostat Hydrochloride Hydrate is a potent inhibitor of HDAC with IC50?of 7.5-16 nM. It is used in the treatment of muscular dystrophy.

Biochem/physiol Actions

Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. Givinostat posseses a very promising activity profile in multiple myeloma and acute myelogenous leukemia in vitro and in vivo. Givinostat also has anti-inflammatory activity and inhibits the secretion of the tumor necrosis factor-alpha (TNF-α), IL-1, and IL-6. Givinostat has been in multiple Phase 2 studies for both inflammatory diseases (Duchenne Muscular Dystrophy , Juvenile arthritis, Polycythemia Vera) and blood cancers (myelomas and lymphomas).

ITF2357 Preparation Products And Raw materials

Raw materials

Preparation Products

ITF2357 Suppliers

Global( 102)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9626 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
Hangzhou FandaChem Co.,Ltd. 55
career henan chemical co 58
Finetech Industry Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58

ITF2357 Spectrum

ITF2357(732302-99-7)MS

732302-99-7(ITF2357)Related Search:

[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester AR-42 Panobinostat JNJ-26481585 Mocetinostat (MGCD0103)
Vorinostat Entinostat
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(6-((diethylamino)methyl)naphthalen-2-yl)methyl 4-(hydroxycarbamoyl)phenylcarbamate hydrochloride hydrate ITF2357 ITF2357 (Givinostat) N-[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester hydrochloride hydrate Givinostat (hydrochloride monohydrate) Givinostat Hydrochloride Hydrate Givinostat (ITF2357) HCl monohydrate Givinostat(HCl hydrate) CS-1443 Givinostat (ITF2357) hydrochloride monohydrate ITF2357 hydrochloride monohydrate Gavinostat hydrochloride monohydrate Givinostat HCl monohydrate (ITF-2357 ITF2357 ITF-2357 Givinostat hydrochloride monohydrate Givinostat (ITF2357) 732302-99-7 Givinostat hydrochloride,ITF-2357 hydrochloride,Givinostat hydrochloride monohydrate,inhibit,HDAC,Histone deacetylases,Inhibitor 6-[(Diethylamino)methyl]-2-naphthyl]methyl [4-(Hydroxycarbamoyl)phenyl]carbamate Hydrochloride Hydrate 732302-99-7 C24H27N3O4HClH2O Inhibitor Inhibitors