ITF2357
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- ₹13888.48 - ₹55727.1
- Product name: ITF2357
- CAS: 732302-99-7
- MF: C24H30ClN3O5
- MW: 475.9651
- EINECS:200-258-5
- MDL Number:MFCD18385007
- Synonyms:(6-((diethylamino)methyl)naphthalen-2-yl)methyl 4-(hydroxycarbamoyl)phenylcarbamate hydrochloride hydrate;ITF2357;ITF2357 (Givinostat);N-[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester hydrochloride hydrate;Givinostat (hydrochloride monohydrate);Givinostat Hydrochloride Hydrate;Givinostat (ITF2357) HCl monohydrate;Givinostat(HCl hydrate)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1772
- Product descriptionGivinostat hydrochloride hydrate ≥95% (HPLC)
- Packaging5MG
- Price₹13888.48
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1772
- Product descriptionGivinostat hydrochloride hydrate ≥95% (HPLC)
- Packaging25MG
- Price₹55727.1
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1772 | Givinostat hydrochloride hydrate ≥95% (HPLC) | 5MG | ₹13888.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1772 | Givinostat hydrochloride hydrate ≥95% (HPLC) | 25MG | ₹55727.1 | 2022-06-14 | Buy |
Properties
storage temp. :-20°C
solubility :≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
form :powder
color :white to beige
CAS DataBase Reference :732302-99-7
solubility :≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
form :powder
color :white to beige
CAS DataBase Reference :732302-99-7
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-1B, and HD-1A with IC50s = 7.5-16 nM) and reduces the production of several pro-inflammatory cytokines including TNFα, IL-1α, and IL-1β (IC50s = 10-22 nM). ITF 2357 also has activity against cells expressing janus kinase 2 (JAK2)V617F (IC50s = 1-10 nM), a mutated form of the JAK2 enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera.Related product price
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