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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >HDAC inhibitors >N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Structure
  • ₹0
  • Product name: N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide
  • CAS: 726169-73-9
  • MF: C23H20N6O
  • MW: 396.44
  • EINECS:
  • MDL Number:MFCD10565970
  • Synonyms:MGCD0103(Mocetinostat);MG0103;Mocetinostat (MGCD0103,MG0103);N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide;Mocetinostat (MGCD0103);N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Mocetinostat (MGCD0103);Mocetinostat, >=98%;N-(2-Aminophenyl)-4-[[[4-(3-pyridyl)pyrimidin-2-yl]amino]methyl]benzamide
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>170oC (dec.)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :RT
solubility :Soluble in DMSO (up to 25 mg/ml)
pka :13.13±0.70(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Mocetinostat is an orally available inhibitor of histone deacetylases (HDACs) that selectively targets HDAC1 and 2 (IC50s = 0.15 and 0.29 μM, respectively), less potently inhibits HDAC3 and 11 (IC50s = 1.66 and 0.59 μM, respectively) and has negligible actions against HDAC4-8. It induces hyperacetylation of histones, causes cell cycle blockade, and induces apoptosis in cancer cells in vitro. Mocetinostat also has antitumor activity in vivo, blocking the growth of human tumor xenografts in mice. It also significantly reduces cardiac fibrosis following ischemic heart failure in mice.

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Suppliers and manufacturers

career henan chemical co
N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide
₹1.00 /1KG
N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide CAS: 726169-73-9
A.J Chemicals
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem