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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Apoptosis >IAP inhibitors >Birinapant

Birinapant

Birinapant Structure
CAS No.
1260251-31-7
Chemical Name:
Birinapant
Synonyms
CS-801;TL 32711;Birinapan;Birinapant;SMAC mimetic;TL-32711 ≥98%;Birinapant, >=98%;Birinapant (TL32711);TL 32711. Birinapant;Birinapant USP/EP/BP
CBNumber:
CB12658183
Molecular Formula:
C42H56F2N8O6
Molecular Weight:
806.94
MOL File:
1260251-31-7.mol
Modify Date:
2025/4/28 21:36:36
Request For Quotation

Birinapant Properties

Melting point >245oC (dec.)
Boiling point 1090.5±65.0 °C(Predicted)
Density 1.320±0.06(20.0000℃)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 13.99±0.46(Predicted)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338
HS Code  29339900

Birinapant Chemical Properties,Uses,Production

Description

Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations. Birinapant causes rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation in breast cancer cells. It shows in vivo antitumor activity, inducing apoptosis in several types of cancer xenografts in mice.

Enzyme inhibitor

This rotationally symmetric SMAC mimetic antagonist and anticancer agent (FW = 806.94 g/mol; CAS 1260251-31-7) targets cellular Inhibitor of Apoptosis Protein (or cIAP1; Kd of <1 nM), arguably the most potent mammalian caspase inhibitor, showing single-agent efficacy due to its panIAP antagonism and causing rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation. When administered in combination with TNF-α, Birinapant is effective against a melanoma cell line with acquired resistance to BRAF inhibitors

Birinapant Preparation Products And Raw materials

Raw materials

Preparation Products

Birinapant Suppliers

Global( 150)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19552 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32222 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30230 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22855 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15417 58 Inquiry
Finetech Industry Limited +86-27-8746-5837 +8619945049750 China 9642 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Dideu Industries Group Limited 58
AFINE CHEMICALS LIMITED 58
Finetech Industry Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58

Birinapant Spectrum

Birinapant(1260251-31-7)1HNMR

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Birinapant Birinapant (TL32711) TL 32711 Birinapant(TL32711)/TL-32711/TL32711/TL-32711 (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-, (2S,2'S)- (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide Birinapant TL 32711 Birinapant (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide Birinapant, >=98% (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]b Birinapant, Free Base Birinapan TL-32711 ≥98% (2S,2'S)-N,N'-[(6,6'-DIFLUORO[2,2'-BI-1H-INDOLE]-3,3'-DIYL)BIS[METHYLENE[(2R,4S)-4-HYDROXY-2,1-PYRRO TL 32711. Birinapant TL-32711; TL32711; TL 32711. BIRINAPANT CS-801 Birinapant USP/EP/BP (2S,2'S)-N,N'-((2S,2'S)-((3S,3'S,5R,5'R)-5,5'-((6,6'-Difluoro-1H,1'H-[2,2'-biindole]-3,3'-diyl)bis(methylene))bis(3-hydroxypyrrolidine-5,1-diyl))bis(1-oxobutane-2,1-diyl))bis(2-(methylamino)propanamide) SMAC mimetic Birinapant, 10 mM in DMSO 1260251-31-7 C42H56F2N8O6 Inhibitors Inhibitor