(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID
![(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Structure](CAS/GIF/16626-02-1.gif)
- CAS No.
- 16626-02-1
- Chemical Name:
- (S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID
- Synonyms
- H-L-Trp(5-F)-OH*H2O;L-5-FLUOROTRYPTOPHAN;5-FLUORO-L-TRYPTOPHAN;H-5-FLUORO-TRP-OH H2O;Tryptophan Impurity 54;5-fluoro-L-tryptophans;L-Tryptophan, 5-fluoro-;5-Fluoro-tryptophan monohydrate;L-5-fluorotryptophan monohydrate;5-FLUORO-L-TRYPTOPHAN MONOHYDRATE
- CBNumber:
- CB1274150
- Molecular Formula:
- C11H11FN2O2
- Molecular Weight:
- 222.22
- MOL File:
- 16626-02-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2022/12/30 16:20:48
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
F | 10 |
HS Code | 2933998090 |
(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Chemical Properties,Uses,Production
Uses
Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR.
Biochem/physiol Actions
5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp. However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.
Purification Methods
Recrystallise it from EtOH, aqueous EtOH or AcOH. Also purify it by passage through a Dowex AG1x2 (acetate form) column and recrystallise the L-enantiomer (from enzymic enrichment) from H2O/EtOH, m 158-163o(dec), [] D -8.3o (c 2.5, N NaOH). [Coy et al. Biochemistry 13 3550 1974, Beilstein 22/14 V 116.]
(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID Suppliers
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A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
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Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
DONBOO AMINO ACID COMPANY | +8613063595538 | China | 9365 | 58 | Inquiry |
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Kanghua (Shanghai) New Drug Development Co., Ltd. | 021-61263370 18901917034 | China | 5637 | 58 | Inquiry |
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