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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Thiophene compounds > 2-(4-Fluorophenyl)-thiophene

2-(4-Fluorophenyl)-thiophene

2-(4-Fluorophenyl)-thiophene Structure
CAS No.
58861-48-6
Chemical Name:
2-(4-Fluorophenyl)-thiophene
Synonyms
2-(4-FL;AKOS BAR-1344;Canagliflozin INT2;IFLAB-BB F2108-0130;Impurity of caglitazin;FLUOROPHENYL)THIOPHENE;Cagliflozin Impurity 14;2-(4-Fluorphenyl)thiophen;Capagliflozin impurity 57;2-(4-fluorophenyl)thiophen
CBNumber:
CB1294813
Molecular Formula:
C10H7FS
Molecular Weight:
178.23
MOL File:
58861-48-6.mol
Modify Date:
2024/12/3 16:17:04
Request For Quotation

2-(4-Fluorophenyl)-thiophene Properties

Melting point 51.0 to 55.0 °C
Boiling point 252.3±15.0 °C(Predicted)
Density 1.200±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility soluble in Methanol
form powder to crystal
color Light orange to Yellow to Green
InChI InChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H
InChIKey PURJRGMZIKXDMW-UHFFFAOYSA-N
SMILES C1(C2=CC=C(F)C=C2)SC=CC=1
CAS DataBase Reference 58861-48-6

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312
HS Code  2934999090

2-(4-Fluorophenyl)-thiophene price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) F0724 2-(4-Fluorophenyl)thiophene min. 95.0 % 58861-48-6 1G ₹4800 2022-05-26 Buy
TCI Chemicals (India) F0724 2-(4-Fluorophenyl)thiophene min. 95.0 % 58861-48-6 5G ₹11000 2022-05-26 Buy
Product number Packaging Price Buy
F0724 1G ₹4800 Buy
F0724 5G ₹11000 Buy

2-(4-Fluorophenyl)-thiophene Chemical Properties,Uses,Production

Chemical Properties

white solid

Uses

2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.

Synthesis

4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene.

2-(4-Fluorophenyl)-thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

5-(4-Fluorophenyl)thiophene-2-carboxylic acid (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone

2-(4-Fluorophenyl)-thiophene Suppliers

Global( 371)Suppliers
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BTC pharm India +918790379245 AndhraPradesh, India 1262 58 Inquiry
GLR Innovations +91 9891111994 New Delhi, India 4535 58 Inquiry
SPC LIFESCIENCES PVT. LTD +91-91-265-2658894 +91-9998016172 Gujarat, India 48 58 Inquiry
SPD CHEMICALS +91-7075800742 +91-7075800742 Hyderabad, India 212 58 Inquiry
Sris Synthesis Pvt Ltd., +91-9989522441 +91-9989522441 Hyderabad, India 281 58 Inquiry
SRINIVASA LABS +91-8247888505 +91-8247888505 Hyderabad, India 76 58 Inquiry
Aether Industries Limited +91-261-6603130 +91-2616603130 Gujarat, India 145 58 Inquiry
Crams Technologies 0129-4011068 New Delhi, India 39 58 Inquiry
Lakshmi Farmachem +91-9948795885 +91-9550886476 Telangana, India 407 58 Inquiry
Denisco Chemicals Pvt Ltd +91-9989050751 Telangana, India 249 58 Inquiry
Supplier Advantage
BTC pharm India 58
GLR Innovations 58
SPC LIFESCIENCES PVT. LTD 58
SPD CHEMICALS 58
Sris Synthesis Pvt Ltd., 58
SRINIVASA LABS 58
Aether Industries Limited 58
Crams Technologies 58
Lakshmi Farmachem 58
Denisco Chemicals Pvt Ltd 58

58861-48-6( 2-(4-Fluorophenyl)-thiophene)Related Search:

3-AMINO-2-CYANO-5-(4-FLUOROPHENYL)THIOPHENE,3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBONITRILE METHYL 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLATE DUP-697 Ethyl 2-amino-4-(4-fluorophenyl)thiophene-3-carboxylate ,98% 3-AMINO-2-CYANO-5-(4-FLUOROPHENYL)THIOPHENE,3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBONITRILE
3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXAMIDE 5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI& 6-(4-FLUOROPHENYL)-3,4-DIHYDROTHIENO[3,2-D]-PYRIMIDIN-4-ONE METHYL 5-(4-FLUOROPHENYL)-2-THIOPHENECARBOXYLATE 4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE
Methyl 2-[(chloroacetyl)amino]-4-(4-fluorophenyl)-thiophene-3-carboxylate 2-Amino-N-(2-fluorophenyl)thiophene-3-carboxamide Isopropyl 2-amino-4-(4-fluorophenyl)thiophene-3-carboxylate N-(5-amino-2-fluorophenyl)thiophene-2-sulfonamide 5-(3-fluorophenyl)thiophene-2-carboxylic acid
methyl 2-[(cyanoacetyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate ethyl 2-amino-4-(3-fluorophenyl)thiophene-3-carboxylate N-(3-amino-4-fluorophenyl)thiophene-2-carboxamide
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IFLAB-BB F2108-0130 2-(4-FLUOROPHENYL)THIOPHENE AKOS BAR-1344 Thiophene, 2-(4-fluorophenyl)- Canagliflozin Intermediate I Canagliflozin INT2 2-(4-fluorophenyl)thiophen Canagliflozin Related Impurity 14 Cagliflozin Impurity 14 2-(4-Fluorophenyl)thiophene> 2-(4-FL Impurity of caglitazin 2-(4-FLUOROPHENYL)THIOPHENE 58861-48-6 2-(4-FLUOROPHENYL)THIOPHENE ISO 9001：2015 REACH Canagliflozin intermediate 2-(4-Fluorphenyl)thiophen 2-(p-Fluorophenyl)thiophene FLUOROPHENYL)THIOPHENE Capagliflozin impurity 57 58861-48-6 58861-48-6